2. Gene
  3. Ptk2b - PTK2 protein tyrosine kinase 2 beta Gene

Ptk2b - PTK2 protein tyrosine kinase 2 beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CAKB; FAK2; PYK2; CADTK; FADK2; Raftk; CAKbeta; E430023O05Rik

基因 ID: 19229 | 基因类型: protein coding

关于 Ptk2b

功能概要

Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including regulation of cell migration; regulation of intracellular signal transduction; and regulation of phosphate metabolic process. Acts upstream of or within cellular response to fluid shear stress and protein phosphorylation. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and heart. Human ortholog(s) of this gene implicated in breast Cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2b 基因产物(4)

mRNA Protein Name
NM_001162365.1 NP_001155837.1 protein-tyrosine kinase 2-beta isoform 2
NM_001162366.2 NP_001155838.1 protein-tyrosine kinase 2-beta isoform 1
NM_001360233.1 NP_001347162.1 protein-tyrosine kinase 2-beta isoform 1
NM_172498.3 NP_766086.2 protein-tyrosine kinase 2-beta isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
17537919 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11238453 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
11274221 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bone resorption IMP
IMP: 通过突变表型推断
14739300 MGI
acts upstream of or within cellular response to fluid shear stress IMP
IMP: 通过突变表型推断
24841674 MGI
involved in chemokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
12960403 MGI
involved in cortical cytoskeleton organization IMP
IMP: 通过突变表型推断
12960403 MGI
involved in marginal zone B cell differentiation IMP
IMP: 通过突变表型推断
10881171 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
19880522 MGI
involved in negative regulation of bone mineralization IMP
IMP: 通过突变表型推断
17537919 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
17537919 MGI
involved in positive regulation of B cell chemotaxis IMP
IMP: 通过突变表型推断
10881171 MGI
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
17698736 MGI
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
19880522 MGI
involved in positive regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
17698736 MGI
acts upstream of positive effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
12960403 MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
19880522 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
11274221 MGI
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
12960403 MGI
involved in regulation of macrophage chemotaxis IMP
IMP: 通过突变表型推断
12960403 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: 通过直接分析推断
28555636 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: 通过突变表型推断
28555636 MGI
involved in regulation of release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
12960403 MGI
involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
21640103 MGI
involved in vascular endothelial growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
17698736 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
28555636 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
28555636 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19880522 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
24841674 MGI
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
28555636 MGI
is active in presynapse IDA
IDA: 通过直接分析推断
28555636 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein-tyrosine kinase 2-beta

CAK-beta

calcium-dependent tyrosine kinase

calcium-regulated non-receptor proline-rich tyrosine kinase

cell adhesion kinase beta

cellular adhesion kinase beta

focal adhesion kinase 2

proline-rich tyrosine kinase 2

related adhesion focal tyrosine ki

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.28% 否
HY-RS11402 PTK2B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20473 Ptk2b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26981 Ptk2b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptk2b NCBI NCBI:2185
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