2. Gene
  3. Ptpn1 - protein tyrosine phosphatase, non-receptor type 1 Gene

Ptpn1 - protein tyrosine phosphatase, non-receptor type 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PTP1B; PTP-1B; PTP-HA2

基因 ID: 19246 | 基因类型: protein coding

关于 Ptpn1

功能概要

Predicted to enable several functions, including protein Phosphatase 2A binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; negative regulation of signal transduction; and peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Acts upstream of or within Insulin Receptor signaling pathway and protein dephosphorylation. Located in early endosome and sorting endosome. Is expressed in central nervous system; midbrain; and superior colliculus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine Phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn1 基因产物(1)

mRNA Protein Name
NM_011201.3 NP_035331.3 tyrosine-protein phosphatase non-receptor type 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
15632081 MGI
enables protein tyrosine phosphatase activity IMP
IMP: 通过突变表型推断
17068137 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in IRE1-mediated unfolded protein response IMP
IMP: 通过突变表型推断
15465829 MGI
involved in insulin receptor recycling IMP
IMP: 通过突变表型推断
17068137 MGI
acts upstream of or within insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
15632081 MGI
involved in negative regulation of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
23639442 MGI
involved in negative regulation of PERK-mediated unfolded protein response IMP
IMP: 通过突变表型推断
21216966 MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21216966 MGI
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
23639442 MGI
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: 通过突变表型推断
14966296 MGI
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IGI
IGI: 通过遗传相互作用推断
23639442 MGI
involved in platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: 通过突变表型推断
14966296 MGI
acts upstream of positive regulation of JUN kinase activity IMP
IMP: 通过突变表型推断
15465829 MGI
acts upstream of or within protein dephosphorylation IMP
IMP: 通过突变表型推断
15632081 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
15465829 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21216966 MGI
located in early endosome IDA
IDA: 通过直接分析推断
23639442 MGI
is active in endosome lumen IDA
IDA: 通过直接分析推断
23639442 MGI
located in sorting endosome IDA
IDA: 通过直接分析推断
23639442 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type 1

protein-protein-tyrosine phosphatase HA2

protein-tyrosine phosphatase 1B

protein-tyrosine phosphatase HA2

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-145923 Osunprotafib Inhibitor 99.43% Phase 1
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153446 Tegeprotafib Inhibitor 99.30% 否
HY-156606 Anticancer agent 142 Inhibitor / 否
HY-RS11415 PTPN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17205 Ptpn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23657 Ptpn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptpn1 NCBI NCBI:5770
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z