2. Gene
  3. RAB12 - RAB12, member RAS oncogene family Gene

RAB12 - RAB12, member RAS oncogene family Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAB12，RAS 致癌基因家族成员

种属: Homo sapiens

基因 ID: 201475 | 基因类型: protein coding

关于 RAB12

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:8,609,437-8,639,383 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 68 paralogues. Ubiquitous expression in heart (RPKM 8.8), fat (RPKM 6.8) and 25 other tissues.

功能概要

启用 GDP 绑定活动。预计参与多个过程，包括细胞对胰岛素刺激的反应；内体到溶酶体的运输；和细胞分泌。预计在细胞对干扰素-γ 的反应上游或细胞反应中起作用。预计位于溶酶体；吞噬泡;和回收内体膜。预测高尔基体活跃；细胞质囊泡；和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables GDP binding activity. Predicted to be involved in several processes, including cellular response to Insulin stimulus; endosome to lysosome transport; and secretion by cell. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in lysosome; phagocytic vesicle; and recycling endosome membrane. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAB12 基因产物(1)

mRNA Protein Name
NM_001025300.3 NP_001020471.3 ras-related protein Rab-12
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP binding IDA
IDA: 通过直接分析推断
20937701 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26824392 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB12 蛋白结构

Ras

Ras: Ras family (45 - 205)

  • 0
  • 100
  • 200
  • 244 a.a.
蛋白主名 其他名称

ras-related protein Rab-12

putative Ras-related protein Rab-12

RAB12 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAB12 Q6IQ22 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
26824392
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Newfoundland Rod-Cone Dystrophy

Newfoundland Cone-Rod Dystrophy

NFRCD

Rod-Cone Dystrophy Newfoundland
Periampullary Adenocarcinoma
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11521 RAB12 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RAB12 MGD MGI:894284
Rattus norvegicus RAB12 RGD RGD:3527
Felis catus RAB12 VGNC VGNC:80472
Bos taurus RAB12 VGNC VGNC:33620
Macaca mulatta RAB12 VGNC VGNC:104237
Canis familiaris RAB12 VGNC VGNC:103700
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