Tgfbr1 - transforming growth factor, beta receptor I Gene

中文名称：转化生长因子， β 受体 I

种属: Mus musculus

同用名: ALK5; ESK2; Alk-5; TGFR-1; TbetaRI; TbetaR-I

关于 Tgfbr1

功能概要

该基因编码转化生长因子 β (TGF-β) 受体蛋白家族的成员。这些蛋白质包含 TGF-β 信号转导通路的一个组成部分，该通路将细胞外信号转导为基因表达变化，以调节广泛的细胞反应，包括增殖、迁移、分化和凋亡。该基因的纯合基因敲除小鼠表现出受损的血管生成和胚胎致死率。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 8 月]

This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and Apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]