2. Gene
  3. Vwf - Von Willebrand factor Gene

Vwf - Von Willebrand factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: VWD; F8VWF; C630030D09; 6820430P06Rik; B130011O06Rik

基因 ID: 22371 | 基因类型: protein coding

关于 Vwf

功能概要

Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and Integrin binding activity. Acts upstream of or within several processes, including liver development; placenta development; and platelet activation. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; leptomeninges; and vitelline blood vessel. Used to study von Willebrand's disease and von Willebrand's disease 2. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor). [provided by Alliance of Genome Resources, Apr 2022]

Vwf 基因产物(1)

mRNA Protein Name
NM_011708.4 NP_035838.3 von Willebrand factor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18281502 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within activation of blood coagulation via clotting cascade IDA
IDA: 通过直接分析推断
30573509 MGI
acts upstream of or within blood coagulation IMP
IMP: 通过突变表型推断
9689113 MGI
acts upstream of or within cell-substrate adhesion IMP
IMP: 通过突变表型推断
11071623 MGI
acts upstream of or within hemostasis IMP
IMP: 通过突变表型推断
9689113 MGI
acts upstream of or within inflammatory response IDA
IDA: 通过直接分析推断
30573509 MGI
acts upstream of or within liver development IMP
IMP: 通过突变表型推断
7854452 MGI
acts upstream of or within placenta development IMP
IMP: 通过突变表型推断
7854452 MGI
NOT acts upstream of or within platelet activation IMP
IMP: 通过突变表型推断
17380206 MGI
acts upstream of or within platelet activation IMP
IMP: 通过突变表型推断
10930441 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Weibel-Palade body IDA
IDA: 通过直接分析推断
30573509 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
8562500 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
30573509 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

von Willebrand factor

Von Willebrand factor homolog

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99227 Caplacizumab Inhibitor ≥99.0% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-153999 BT200 Inhibitor 98.20% Phase 2
HY-147079 Egaptivon pegol Inhibitor 92.75% Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153999A BT200 sodium 98.20% 否
HY-147079A Egaptivon pegol sodium Inhibitor 92.75% 否
HY-P5354 FRETS-VWF73 / 否
HY-RS15735 VWF Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-153998 BT100 sodium Inhibitor / 否
HY-RS17403 Vwf Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23858 Vwf Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990544 Anti-vWF Antibody / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Vwf NCBI NCBI:7450
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