2. Gene
  3. RASA3 - RAS p21 protein activator 3 Gene

RASA3 - RAS p21 protein activator 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAS p21 蛋白激活因子 3

种属: Homo sapiens

同用名: GAPIII; GAP1IP4BP

基因 ID: 22821 | 基因类型: protein coding

关于 RASA3

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,977,783-114,132,623 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 216 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 14.2), lymph node (RPKM 12.1) and 25 other tissues.

功能概要

该基因编码的蛋白质可结合肌醇 1,3,4,5-四磷酸并刺激 Ras p21 的 GTP 酶活性。这种蛋白质作为 Ras 信号通路的负调节剂发挥作用。它通过 C 末端区域的 pleckstrin 同源 (PH) 结构域定位于细胞膜。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 3 月]

This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

RASA3 基因产物(3)

mRNA Protein Name
NM_001320821.2 NP_001307750.1 ras GTPase-activating protein 3 isoform 2
NM_001320822.2 NP_001307751.1 ras GTPase-activating protein 3 isoform 3
NM_007368.4 NP_031394.2 ras GTPase-activating protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel regulator activity IDA
IDA: 通过直接分析推断
10828023 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in platelet activation IDA
IDA: 通过直接分析推断
10828023 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
10828023 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RASA3 蛋白结构

C2

C2: C2 domain (15 - 95)

C2

C2: C2 domain (149 - 246)

RasGAP

RasGAP: GTPase-activator protein for Ras-like GTPase (351 - 523)

PH

PH: PH domain (578 - 675)

BTK

BTK: BTK motif (685 - 714)

  • 0
  • 200
  • 400
  • 600
  • 834 a.a.
蛋白主名 其他名称

ras GTPase-activating protein 3

GTPase activating protein III

关联疾病

疾病名称 别名
Paralytic Poliomyelitis

Poliomyelitis, Paralytic
Poliomyelitis

Polio

Infantile Paralysis
Acquired Thrombocytopenia

Secondary Thrombocytopenia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11680 RASA3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21719 Rasa3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28237 Rasa3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RASA3 VGNC VGNC:64496
Macaca mulatta RASA3 VGNC VGNC:76513
Canis familiaris RASA3 VGNC VGNC:45361
Rattus norvegicus RASA3 RGD RGD:69365
Bos taurus RASA3 VGNC VGNC:33737
Mus musculus RASA3 MGD MGI:1197013
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