ZHX2 - zinc fingers and homeoboxes 2 Gene

中文名称：锌指和同源盒 2

种属: Homo sapiens

同用名: RAF; AFR1

基因 ID: 22882 | 基因类型: protein coding

关于 ZHX2

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:122,781,655-122,974,510 (from NCBI)

This gene has 2 transcripts (splice variants), 237 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 12.8), lymph node (RPKM 11.9) and 25 other tissues.

功能概要

锌指和同源框基因家族的成员是与核因子-Y (NF-YA) 的 A 亚基相互作用的核同源二聚体转录抑制因子，包含两个 C2H2 型锌指和五个同源框 DNA 结合域。该基因编码该基因家族的成员 2。除了形成同源二聚体之外，该蛋白质还与锌指和同源框家族的成员 1 异源二聚化。[RefSeq 提供，2008 年 7 月]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

ZHX2 基因产物(11)

mRNA	Protein	Name
XM_047421585.1	XP_047277541.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_047421584.1	XP_047277540.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_047421589.1	XP_047277545.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_005250836.6	XP_005250893.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_047421588.1	XP_047277544.1	zinc fingers and homeoboxes protein 2 isoform X1
NM_001362797.2	NP_001349726.1	zinc fingers and homeoboxes protein 2
XM_047421590.1	XP_047277546.1	zinc fingers and homeoboxes protein 2 isoform X1
NM_014943.5	NP_055758.1	zinc fingers and homeoboxes protein 2
XM_047421586.1	XP_047277542.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_011516932.4	XP_011515234.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_047421587.1	XP_047277543.1	zinc fingers and homeoboxes protein 2 isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	12741956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12741956	GOA
enables protein heterodimerization activity	IDA IDA: 通过直接分析推断	12741956	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	12741956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12741956	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12741956	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in nucleus	IDA IDA: 通过直接分析推断	17056598	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12741956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZHX2 蛋白结构

zf-H2C2_5

Homeobox

0
200
400
600
837 a.a.

蛋白主名

其他名称

zinc fingers and homeoboxes protein 2

AFP regulator 1	alpha-fetoprotein regulator 1
regulator of AFP	transcription factor ZHX2
zinc finger and homeodomain protein 2

ZHX2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ZHX2	Q9Y6X8	TFF2	Homo sapiens	Q03403	Y2H Pooling	32814053
种属内	ZHX2	Q9Y6X8	TFF2	Homo sapiens	Q03403	Validated Y2H	32814053
种属内	ZHX2	Q9Y6X8	TFF2	Homo sapiens	Q03403	Y2H Array	32814053
种属内	ZHX2	Q9Y6X8	AIFM1	Homo sapiens	O95831	Crosslink	30021884
种属内	ZHX2	Q9Y6X8	ZHX2	Homo sapiens	Q9Y6X8	Y2H	12741956
种属内	ZHX2	Q9Y6X8	ZHX2	Homo sapiens	Q9Y6X8	Pull Down	12741956
种属内	ZHX2	Q9Y6X8	Arfgap1	Rattus norvegicus	Q62848	GTPase Assay	22363216

种属间: 跨种属相互作用 种属内: 同种属相互作用

ZHX2 抗体

目录号	产品名	应用	反应物种
HY-P82001	ZHX2 Antibody (YA1746)	WB, ICC/IF	Human, Rat

关联疾病

疾病名称

别名

Fetal Hemoglobin Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin	Delta-Beta-Thalassemia
Delta-Beta Thalassemia	Delta Beta-Thalassemia
HBFQTL1	Hemoglobin F, Hereditary Persistence Of
Hpfh	Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related
Hemoglobin, Fetal, Quantitative Trait Locus 1	Hereditary Persistence Of Fetal Hemoglobin Thalassemia
Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]	Fetal Haemoglobin
Persistence Of Fetal Haemoglobin	Persistent Haemoglobin F

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency	Mitochondrial Complex Iv Deficiency
Cox Deficiency	Cytochrome-C Oxidase Deficiency Disease
MC1DN4	Cytochrome-C Oxidase Deficiency
MC4DN1	Mitochondrial Complex I Deficiency, Nuclear Type 4
Complex 4 Mitochondrial Respiratory Chain Deficiency	Complex Iv Deficiency
Mitochondrial Complex 1 Deficiency, Nuclear Type 4	Nuclear Type Mitochondrial Complex I Deficiency 4
Deficiency Of Mitochondrial Respiratory Chain Complex4	MT-C4D
Complex Iv Mitochondrial Respiratory Chain Deficiency	Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Nephrotic Syndrome, Type 23

NPHS23	Nephrotic Syndrome Type 23
Nephrotic Syndrome 23

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16069	ZHX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS16070	Zhx2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS16071	Zhx2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ZHX2	MGD	MGI:2683087
Canis familiaris	ZHX2	VGNC	VGNC:48632
Bos taurus	ZHX2	VGNC	VGNC:37183
Rattus norvegicus	ZHX2	RGD	RGD:727926
Macaca mulatta	ZHX2	VGNC	VGNC:79148
Felis catus	ZHX2	VGNC	VGNC:67244

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4