2. Gene
  3. CAMTA2 - calmodulin binding transcription activator 2 Gene

CAMTA2 - calmodulin binding transcription activator 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙调蛋白结合转录激活因子 2

种属: Homo sapiens

基因 ID: 23125 | 基因类型: protein coding

关于 CAMTA2

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,967,997-4,987,675 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 16.2), testis (RPKM 10.6) and 25 other tissues.

功能概要

由该基因编码的蛋白质是钙调蛋白结合转录激活蛋白家族的成员。该家族的成员共享一个共同的结构域结构，该结构由转录激活结构域、DNA 结合结构域和钙调蛋白结合结构域组成。编码的蛋白质可能是参与心脏生长的基因的转录共激活因子。交替剪接导致多个转录变体。[RefSeq 提供，2010 年 1 月]

The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]

CAMTA2 基因产物(4)

mRNA Protein Name
NM_001171166.2 NP_001164637.1 calmodulin-binding transcription activator 2 isoform 2
NM_001171167.2 NP_001164638.1 calmodulin-binding transcription activator 2 isoform 4
NM_001171168.2 NP_001164639.1 calmodulin-binding transcription activator 2 isoform 3
NM_015099.4 NP_055914.2 calmodulin-binding transcription activator 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
16678093 GOA
enables histone deacetylase binding IDA
IDA: 通过直接分析推断
16678093 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16678093 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
16678093 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cardiac muscle hypertrophy in response to stress IDA
IDA: 通过直接分析推断
16678093 GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16678093 GOA
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16678093 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
16678093 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16678093 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAMTA2 蛋白结构

CG-1

CG-1: CG-1 domain (35 - 149)

TIG

TIG: IPT/TIG domain (534 - 614)

IQ

IQ: IQ calmodulin-binding motif (1102 - 1122)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1202 a.a.
蛋白主名 其他名称

calmodulin-binding transcription activator 2

CAMTA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
CAMTA2 O94983 Nkx2-5 Mus musculus P42582
Pull Down
16678093
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 22

RP22

Retinitis Pigmentosa-22
Hereditary Lymphedema I

Lymphedema

Hereditary Lymphedema Type I

Congenital Primary Lymphedema

Lmph1

Milroy Disease

Nonne-Milroy Lymphedema

Pcl

Lymphedema Hereditary Type 1
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01875 CAMTA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CAMTA2 VGNC VGNC:60343
Mus musculus CAMTA2 MGD MGI:2135957
Canis familiaris CAMTA2 VGNC VGNC:38693
Rattus norvegicus CAMTA2 RGD RGD:1311296
Macaca mulatta CAMTA2 VGNC VGNC:70578
Bos taurus CAMTA2 VGNC VGNC:26733
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