CES3 - carboxylesterase 3 Gene

中文名称：羧酸酯酶 3

种属: Homo sapiens

同用名: ES31

关于 CES3

功能概要

该基因编码羧酸酯酶大家族的成员。该家族成员负责各种异生素 (如可卡因和海洛因) 以及具有酯、硫酯或酰胺键的内源性底物的水解或酯交换。它们可能参与脂肪酰和胆固醇酯的代谢，并可能在血脑屏障系统中发挥作用。该基因在多个组织中表达，特别是在结肠、气管和脑中，该蛋白参与结肠和神经药物代谢。已经报道了编码不同同种型的多个选择性剪接转录本变体，但尚未确定某些变体的生物学有效性和/或全长性质。[RefSeq 提供，2010 年 6 月]

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and Cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]