2. Gene
  3. Grem1 - gremlin 1, DAN family BMP antagonist Gene

Grem1 - gremlin 1, DAN family BMP antagonist Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ld; Drm; Grem; Cktsf1b1

基因 ID: 23892 | 基因类型: protein coding

关于 Grem1

功能概要

Enables receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; nephron epithelium morphogenesis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of branching involved in ureteric bud morphogenesis; and regulation of signal transduction. Located in extracellular space. Colocalizes with cell surface. Is expressed in several structures, including embryo mesenchyme; limb bud; neural ectoderm; sensory organ; and skeleton. Orthologous to human GREM1 (gremlin 1, Dan family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Grem1 基因产物(2)

mRNA Protein Name
NM_011824.4 NP_035954.1 gremlin-1 precursor
NM_011824.4 NP_035954.1 gremlin-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables receptor ligand activity IPI
IPI: 通过物理相互作用推断
20660291 MGI
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: 通过直接分析推断
20660291 MGI
enables vascular endothelial growth factor receptor 2 binding IPI
IPI: 通过物理相互作用推断
20660291 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within angiogenesis IDA
IDA: 通过直接分析推断
18505784 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
15198975 MGI
involved in cardiac muscle cell differentiation IDA
IDA: 通过直接分析推断
18545679 MGI
involved in cardiac muscle cell myoblast differentiation IDA
IDA: 通过直接分析推断
18545679 MGI
involved in cell migration involved in sprouting angiogenesis IDA
IDA: 通过直接分析推断
17077323 MGI
acts upstream of or within cell-cell signaling IMP
IMP: 通过突变表型推断
15201225 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: 通过突变表型推断
12808456 MGI
involved in endothelial cell migration IDA
IDA: 通过直接分析推断
17077323 MGI
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
IDA: 通过直接分析推断
17522159 MGI
acts upstream of or within negative regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
17522159 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
17522159 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
17522159 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
18505784 MGI
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
17077323 MGI
acts upstream of or within positive regulation of branching involved in ureteric bud morphogenesis IDA
IDA: 通过直接分析推断
21281623 MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis IDA
IDA: 通过直接分析推断
17522159 MGI
acts upstream of or within positive regulation of branching involved in ureteric bud morphogenesis IGI
IGI: 通过遗传相互作用推断
17522159 MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
18505784 MGI
involved in positive regulation of peptidyl-tyrosine autophosphorylation IDA
IDA: 通过直接分析推断
20660291 MGI
involved in positive regulation of protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
17077323 MGI
involved in positive regulation of receptor internalization IDA
IDA: 通过直接分析推断
20660291 MGI
involved in positive regulation of signaling receptor activity IDA
IDA: 通过直接分析推断
20660291 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12135612 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: 通过突变表型推断
12808456 MGI
involved in regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
17077323 MGI
NOT involved in regulation of stress-activated MAPK cascade IDA
IDA: 通过直接分析推断
12135612 MGI
involved in signal transduction IDA
IDA: 通过直接分析推断
20660291 MGI
NOT involved in signal transduction by p53 class mediator IGI
IGI: 通过遗传相互作用推断
12135612 MGI
involved in ureteric bud formation IDA
IDA: 通过直接分析推断
17522159 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with cell surface IDA
IDA: 通过直接分析推断
17077323 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
17077323 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

gremlin-1

cysteine knot superfamily 1, BMP antagonist 1

down-regulated in Mos-transformed cells protein

down-regulated in v-mos-transformed cells

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112056 DIM-C-pPhCO2Me 99.47% 否
HY-RS05784 GREM1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17341 Grem1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23796 Grem1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990426 Anti-GREM1/Gremlin Antibody 98.59% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grem1 NCBI NCBI:26585
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