2. Gene
  3. Cyp11b2 - cytochrome P450, family 11, subfamily b, polypeptide 2 Gene

Cyp11b2 - cytochrome P450, family 11, subfamily b, polypeptide 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ALDOS; Cp45as; Cyp11b3; RNCP45AS

基因 ID: 24294 | 基因类型: protein coding

关于 Cyp11b2

功能概要

Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to nutrient levels; response to peptide hormone; and steroid biosynthetic process. Located in dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B1 (Cytochrome P450 family 11 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11b2 基因产物(1)

mRNA Protein Name
NM_012538.2 NP_036670.2 cytochrome P450 11B2, mitochondrial
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables corticosterone 18-monooxygenase activity IDA
IDA: 通过直接分析推断
2350348 RGD
enables steroid 11-beta-monooxygenase activity IDA
IDA: 通过直接分析推断
8333830 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in C21-steroid hormone biosynthetic process IDA
IDA: 通过直接分析推断
11832364 RGD
involved in aldosterone biosynthetic process IDA
IDA: 通过直接分析推断
11832364 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19478813 RGD
involved in cellular response to nutrient IEP
IEP: 通过表达模式推断
16876110 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: 通过表达模式推断
20685870 RGD
involved in cellular response to potassium ion starvation IEP
IEP: 通过表达模式推断
20685870 RGD
involved in glucocorticoid biosynthetic process IDA
IDA: 通过直接分析推断
11832364 RGD
involved in positive regulation of blood pressure IMP
IMP: 通过突变表型推断
18495825 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
16043663 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
16882930 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
18252953 RGD
involved in response to salt stress IEP
IEP: 通过表达模式推断
19118098 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16043663 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
12459034 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cytochrome P450 11B2, mitochondrial

CYPXIB2

CYPXIB3

Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase)

P450-Aldo-1

P450-Aldo-2

aldosterone synthase

aldosterone-synthesizing enzyme

corticosterone 18-monooxygenase, CYP11B2

cytochrome P-450Aldo

cytochrome P-450C18

c

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16276 Osilodrostat Inhibitor 99.90% 是
HY-16276A Osilodrostat phosphate Inhibitor 99.35% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-19833 Lapiteronel Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-113151 18-Oxocortisol Antagonist 99.86% 否
HY-155493 CYP19A1/CYP11B2-IN-1 Inhibitor 99.85% 否
HY-101217 BI 689648 Inhibitor 99.20% 否
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% 否
HY-176480 CYP11B2-IN-3 Inhibitor / 否
HY-RS03436 CYP11B2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-162574 CYP11B2-IN-2 Inhibitor / 否
HY-163751 STING-IN-9 Inhibitor / 否
HY-RS17177 Cyp11b2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23627 Cyp11b2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W002108 3,4-Dihydroquinolin-2(1H)-one ≥95.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cyp11b2 NCBI NCBI:1585
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