2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Mineralocorticoid Receptor Endogenous Metabolite
  4. 18-Oxocortisol

18-Oxocortisol 

目录号: HY-113151 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

18-Oxocortisol 是由醛固酮合酶 (CYP11B2) 产生的皮质醇衍生物。18-Oxocortisol 是天然存在的盐皮质激素 (mineralocorticoid) 激动剂。18-Oxocortisol 是肾上腺静脉采样中的生物标志物。

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18-Oxocortisol Chemical Structure

18-Oxocortisol Chemical Structure

CAS No. : 2410-60-8

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1 mg ￥7200
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18-Oxocortisol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3].

体内研究
(In Vivo)

Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

376.44

Formula

C21H28O6
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (174 KB)

产品使用指南 (1538 KB)
参考文献

18-Oxocortisol 相关分类

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Keywords:

18-Oxocortisol2410-60-8Mineralocorticoid ReceptorEndogenous MetabolitebiomarkernaturallyderivativeCYP11B2aldosteronismhybridbloodpressureInhibitorinhibitorinhibit

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