1. Gene
  2. Gpx1 - glutathione peroxidase 1 Gene

Gpx1 - glutathione peroxidase 1 Gene

种属: Rattus norvegicus

同用名: GSHPx; GSHPx-1

基因 ID: 24404 | 基因类型: protein coding

关于 Gpx1

功能概要

The protein encoded by this gene belongs to the Glutathione Peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016]

Gpx1 基因产物(1)

mRNA Protein Name
NM_030826.4 NP_110453.3 glutathione peroxidase 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutathione peroxidase activity IDA
IDA: 通过直接分析推断
1640255 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
19944066 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
17211248 RGD
involved in response to folic acid IEP
IEP: 通过表达模式推断
16251605 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
15039483 RGD
involved in response to hormone IEP
IEP: 通过表达模式推断
17561443 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
18343235 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18255150 RGD
involved in response to selenium ion IEP
IEP: 通过表达模式推断
19234057 RGD
involved in response to vitamin E IEP
IEP: 通过表达模式推断
16038882 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

glutathione peroxidase 1

GPx-1

cellular glutathione peroxidase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gpx1 NCBI NCBI:2876