2. Gene
  3. ABCC1 - Abcc1 ATP binding cassette subfamily C member 1 Gene

ABCC1 - Abcc1 ATP binding cassette subfamily C member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Mrp; Mrp1; Abcc1a; Avcc1a

基因 ID: 24565 | 基因类型: protein coding

关于 ABCC1

功能概要

Enables several functions, including ATPase-coupled transmembrane transporter activity; glutathione transmembrane transporter activity; and long-chain fatty acid transporter activity. Involved in several processes, including glutathione transmembrane transport; lipid transport; and xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basolateral plasma membrane and cytoplasm. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 77 and chronic obstructive pulmonary disease. Orthologous to human ABCC1 (ATP binding cassette subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]

ABCC1 基因产物(1)

mRNA Protein Name
NM_022281.2 NP_071617.2 multidrug resistance-associated protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ABC-type xenobiotic transporter activity IDA
IDA: 通过直接分析推断
12867490 RGD
enables ABC-type xenobiotic transporter activity IMP
IMP: 通过突变表型推断
12893836 RGD
enables ATPase-coupled lipid transmembrane transporter activity IDA
IDA: 通过直接分析推断
12867490 RGD
enables amide transmembrane transporter activity IDA
IDA: 通过直接分析推断
12423064 RGD
enables efflux transmembrane transporter activity IDA
IDA: 通过直接分析推断
12423064 RGD
enables glutathione transmembrane transporter activity IMP
IMP: 通过突变表型推断
12125073 RGD
enables long-chain fatty acid transmembrane transporter activity IDA
IDA: 通过直接分析推断
12867490 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in astrocyte differentiation IMP
IMP: 通过突变表型推断
17141959 RGD
involved in cell chemotaxis IMP
IMP: 通过突变表型推断
17050692 RGD
involved in export across plasma membrane IDA
IDA: 通过直接分析推断
15198509 RGD
involved in glial cell differentiation IMP
IMP: 通过突变表型推断
17141959 RGD
involved in glutathione transmembrane transport IMP
IMP: 通过突变表型推断
12125073 RGD
involved in long-chain fatty acid import across plasma membrane IDA
IDA: 通过直接分析推断
12867490 RGD
involved in phospholipid efflux IMP
IMP: 通过突变表型推断
17050692 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
17050692 RGD
involved in regulation of cellular response to drug IDA
IDA: 通过直接分析推断
15198509 RGD
involved in response to oxidative stress IMP
IMP: 通过突变表型推断
11208926 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
14641820 RGD
involved in transmembrane transport IDA
IDA: 通过直接分析推断
12423064 RGD
involved in transmembrane transport IMP
IMP: 通过突变表型推断
17854063 RGD
involved in xenobiotic detoxification by transmembrane export across the plasma membrane IDA
IDA: 通过直接分析推断
12423064 RGD
involved in xenobiotic transport IMP
IMP: 通过突变表型推断
12893836 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basal plasma membrane IDA
IDA: 通过直接分析推断
18619525 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11804835 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

multidrug resistance-associated protein 1

ATP-binding cassette sub-family C ( CFTR/MRP) member 1a

ATP-binding cassette sub-family C member 1

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

ATP-binding cassette, sub-family C, member 1-like

ATP-binding cassette, subfamily C (CFTR/MRP),

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1794 Thiethylperazine 99.91% 否
HY-B1794A Thiethylperazine dimaleate 99.99% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-17013A Dofequidar fumarate Inhibitor ≥98.0% Phase 3
HY-17013D Dofequidar sesquifumarate Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19989A MK-571 sodium 99.75% 否
HY-19989 MK-571 98.85% 否
HY-101453 Ceefourin 1 Inhibitor 99.72% 否
HY-N3610 Coclaurine Antagonist 98.97% 否
HY-113805 MC70 Inhibitor 99.50% 否
HY-17013 Dofequidar Inhibitor 98.17% 否
HY-D1609 BODIPY FL Verapamil hydrochloride / 否
HY-RS00057 ABCC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16913 Abcc1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23355 Abcc1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ABCC1 NCBI NCBI:4363
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