2. Gene
  3. FUT6 - fucosyltransferase 6 Gene

FUT6 - fucosyltransferase 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：岩藻糖基转移酶 6

种属: Homo sapiens

同用名: FT1A; FCT3A; Fuc-TVI; FucT-VI

基因 ID: 2528 | 基因类型: protein coding

关于 FUT6

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,830,408-5,839,702 (from NCBI)

This gene has 11 transcripts (splice variants), 380 orthologues, 7 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 17.3), esophagus (RPKM 12.2) and 8 other tissues.

功能概要

该基因编码的蛋白质是一种高尔基体膜蛋白，参与唾液酸-路易斯 X (一种 E-选择素配体) 的产生。该基因的突变是导致岩藻糖基转移酶 6 缺乏症的原因。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-Selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

FUT6 基因产物(10)

mRNA Protein Name
NM_000150.4 NP_000141.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001040701.2 NP_001035791.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001369502.1 NP_001356431.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001369504.1 NP_001356433.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001369505.1 NP_001356434.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001381955.1 NP_001368884.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001381956.1 NP_001368885.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001381957.1 NP_001368886.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2
NM_001381958.1 NP_001368887.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2
NM_001381959.1 NP_001368888.1 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
IDA: 通过直接分析推断
9363434 GOA
enables fucosyltransferase activity IDA
IDA: 通过直接分析推断
17604274 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-glycan fucosylation IDA
IDA: 通过直接分析推断
9363434 GOA
involved in ceramide metabolic process IDA
IDA: 通过直接分析推断
17604274 GOA
involved in glycosphingolipid biosynthetic process IDA
IDA: 通过直接分析推断
29593094 GOA
involved in protein N-linked glycosylation IDA
IDA: 通过直接分析推断
29593094 GOA
involved in protein O-linked glycosylation IDA
IDA: 通过直接分析推断
29593094 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
9451035 GOA
located in extracellular region IDA
IDA: 通过直接分析推断
9451035 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FUT6 蛋白结构

Glyco_transf_10

Glyco_transf_10: Glycosyltransferase family 10 (fucosyltransferase) C-term (15 - 358)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
蛋白主名 其他名称

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6

alpha-(1,3)-fucosyltransferase 6

关联疾病

疾病名称 别名
Fucosyltransferase 6 Deficiency
Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2

CGL2

Berardinelli-Seip Congenital Lipodystrophy Type 2

Berardinelli-Seip Syndrome

Brunzell Syndrome Bscl2-Related

Total Lipodystrophy And Acromegaloid Gigantism

Berardinelli-Seip Congenital Lipodystrophy, Type 2

Seip Syndrome

Berardinelli Syndrome

Lipodystrophy, Total, And Acromegaloid Gigantism

Lipoatrophic Diabetes, Congenital

Lipodystrophy, Berardinelli-Seip Congenital, Type 2

Brunzell Syndrome, Bscl2-Related

Congenital Lipoatrophic Diabetes

Congenital Generalized Lipodystrophy 2

Lipoatrophic Diabetes

Lipodystrophy Berardinelli Type

Familial Generalized Lipodystrophy

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-E70303 Fucosyltransferase 6 / 否
HY-RS05157 FUT6 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FUT6 RGD RGD:1588473
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