2. Gene
  3. Phb1 - prohibitin 1 Gene

Phb1 - prohibitin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Phb

基因 ID: 25344 | 基因类型: protein coding

关于 Phb1

功能概要

Predicted to enable several functions, including complement binding activity; histone deacetylase binding activity; and protein C-terminus binding activity. Involved in several processes, including female gonad development; positive regulation of protein kinase B signaling; and positive regulation of smooth muscle cell proliferation. Located in mitochondrial crista and nucleus. Is extrinsic component of mitochondrial outer membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of presynaptic active zone membrane. Biomarker of urinary bladder Cancer. Human ortholog(s) of this gene implicated in breast Cancer and sporadic breast Cancer. Orthologous to human PHB (prohibitin). [provided by Alliance of Genome Resources, Apr 2022]

Phb1 基因产物(1)

mRNA Protein Name
NM_031851.2 NP_114039.1 prohibitin 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
9473733 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
17038561 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17043753 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
17043753 RGD
involved in ovarian follicle atresia IEP
IEP: 通过表达模式推断
15028627 RGD
involved in ovarian follicle development IEP
IEP: 通过表达模式推断
15028627 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
32173312 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
32173312 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
17043753 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
16825707 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
15378698 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
12639934 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16470657 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse EXP
EXP: 通过实验结果推断
23622064 RGD
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
23622064 RGD
is active in extrinsic component of presynaptic active zone membrane EXP
EXP: 通过实验结果推断
23622064 RGD
is active in extrinsic component of presynaptic active zone membrane IDA
IDA: 通过直接分析推断
23622064 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
17623647 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17623647 RGD
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
7843414 RGD
is active in postsynaptic density EXP
EXP: 通过实验结果推断
17623647 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
17623647 RGD
is active in synapse IDA
IDA: 通过直接分析推断
18504422 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

prohibitin 1

prohibitin

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114989 Fluorizoline Inducer 99.77% 否
HY-141475 Acetoacetyl coenzyme A sodium / 否
HY-162904 BPU17 / 否
HY-RS10407 PHB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17295 Phb1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23750 Phb1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Phb1 NCBI NCBI:5245
Mus musculus Phb1 NCBI
Macaca mulatta Phb1 NCBI NCBI:699334
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