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  3. P2rx1 - purinergic receptor P2X 1 Gene

P2rx1 - purinergic receptor P2X 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X 1

种属: Rattus norvegicus

同用名: P2XMR

基因 ID: 25505 | 基因类型: protein coding

关于 P2rx1

Primary_assembly 10: 57,618,586-57,633,623 forward strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 199 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in Lung (RPKM 76.9), Spleen (RPKM 54.) and 8 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动；细胞外 ATP 门控阳离子通道活性；和苏拉明结合活性。涉及多个过程，包括谷氨酸能突触传递；神经元动作电位；和细胞溶质钙离子浓度的调节。位于膜筏内；神经元投射；和质膜。部分含蛋白质复合物。在谷氨酸能突触中活跃。是突触后膜的组成部分和突触前活动区膜的组成部分。与人 P2RX1（嘌呤能受体 P2X 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and suramin binding activity. Involved in several processes, including glutamatergic synaptic transmission; neuronal action potential; and regulation of cytosolic calcium ion concentration. Located in membrane raft; neuron projection; and plasma membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic active zone membrane. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Apr 2022]

P2rx1 基因产物(3)

mRNA Protein Name
NM_001285415.1 NP_001272344.1 P2X purinoceptor 1 isoform 3
NM_001142367.2 NP_001135839.1 P2X purinoceptor 1 isoform 2
NM_012997.3 NP_037129.1 P2X purinoceptor 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
16934235 RGD
enables ATP binding IMP
IMP: 通过突变表型推断
17287520 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
16934235 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15313628 RGD
enables nucleotide binding IDA
IDA: 通过直接分析推断
12237343 RGD
enables organic cyclic compound binding IPI
IPI: 通过物理相互作用推断
12237343 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9855626 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
15313628 RGD
enables suramin binding IDA
IDA: 通过直接分析推断
12237343 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in monoatomic cation transmembrane transport IDA
IDA: 通过直接分析推断
7523951 RGD
involved in monoatomic ion transmembrane transport IMP
IMP: 通过突变表型推断
14625300 RGD
involved in neuronal action potential IDA
IDA: 通过直接分析推断
16934235 RGD
involved in positive regulation of calcium ion import across plasma membrane IDA
IDA: 通过直接分析推断
12237343 RGD
involved in regulation of blood pressure IMP
IMP: 通过突变表型推断
14679185 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration EXP
EXP: 通过实验结果推断
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IEP
IEP: 通过表达模式推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: 通过实验结果推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IEP
IEP: 通过表达模式推断
16000618 RGD
involved in synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
16000618 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
16000618 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16000618 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
26801076 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
16000618 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
17287520 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2rx1 蛋白结构

P2X

P2X: TIGR00863 (0 - 367)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

P2X purinoceptor 1

ATP receptor

P2X1

RP-2 protein

purinergic receptor P2X, ligand-gated ion channel, 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09897 P2RX1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS09898 P2rx1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS09899 P2rx1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2rx1 NCBI NCBI:5023
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