GLI4 - GLI family zinc finger 4 Gene

中文名称：GLI 家族锌指 4

种属: Homo sapiens

同用名: HKR4; ZNF928

基因 ID: 2738 | 基因类型: protein coding

关于 GLI4

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,267,445-143,276,931 (from NCBI)

This gene has 11 transcripts (splice variants), 66 orthologues and 174 paralogues. Ubiquitous expression in fat (RPKM 5.3), spleen (RPKM 4.2) and 25 other tissues.

功能概要

预测可实现 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预计参与转录调控，以 DNA 为模板。预测位于核内。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

GLI4 基因产物(1)

mRNA	Protein	Name
NM_138465.4	NP_612474.1	zinc finger protein GLI4

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLI4 蛋白结构

zf-H2C2_2

0
100
200
300
376 a.a.

蛋白主名

其他名称

zinc finger protein GLI4

GLI-Kruppel family member GLI4 (oncogene HKR4)

关联疾病

疾病名称

别名

Parameningeal Embryonal Rhabdomyosarcoma

Heart Fibrosarcoma

Cardiac Fibrosarcoma

Fibrosarcoma Of The Heart

Joubert Syndrome 32

JBTS32

Pleomorphic Rhabdomyosarcoma

Adult Pleomorphic Rhabdomyosarcoma	Anaplastic Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma, Adult Type

46,Xy Sex Reversal 7

SRXY7	46,Xy Sex Reversal, Partial Or Complete, Dhh-Related
46,Xy Gonadal Dysgenesis, Partial Or Complete, Dhh-Related	Gdxym
Gonadal Dysgenesis, Xy, Male-Limited	46xy Sex Reversal 7
Gonadal Dysgenesis, Xy, Male Limited	Complete Pure Gonadal Dysgenesis 46,Xy Type
Male-Limited Gonadal Dysgenesis 46,Xy	46,Xy Gonadal Dysgenesis, Complete Or Partial, Dhh-Related

Holoprosencephaly 9

Pituitary Anomalies With Holoprosencephaly-Like Features	HPE9
Holoprosencephaly With Microphthalmia And First Branchial Arch Anomalies	Holoprosencephaly-9
Holoprosencephaly, Type 9

Holoprosencephaly 7

HPE7	Holoprosencephaly-7
Holoprosencephaly, Type 7

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05477	GLI4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	GLI4	RGD	RGD:1560906
Canis familiaris	GLI4	VGNC	VGNC:41259

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