1. Gene
  2. Abcc5 - ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Gene

Abcc5 - ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Gene

种属: Mus musculus

同用名: Mrp5; Abcc5a; Abcc5b; 2900011L11Rik

基因 ID: 27416 | 基因类型: protein coding

关于 Abcc5

功能概要

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine Anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Abcc5 基因产物(2)

mRNA Protein Name
NM_013790.2 NP_038818.2 ATP-binding cassette sub-family C member 5 isoform 1
NM_176839.1 NP_789809.1 ATP-binding cassette sub-family C member 5 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ABC-type transporter activity IMP
IMP: 通过突变表型推断
17540771 MGI
enables carbohydrate derivative transmembrane transporter activity IMP
IMP: 通过突变表型推断
17540771 MGI
enables macromolecule transmembrane transporter activity IMP
IMP: 通过突变表型推断
17540771 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in hyaluronan biosynthetic process IMP
IMP: 通过突变表型推断
17540771 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
16361063 MGI
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
24836561 MGI
is active in plasma membrane IMP
IMP: 通过突变表型推断
17540771 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

ATP-binding cassette sub-family C member 5

multidrug resistance-associated protein 5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5a

ATP-binding cassette, sub-family C (CFTR/MRP), member 5b

ATP-binding cassette, sub-family C, member 5

MOAT-C

SMRP

multi-specific organic anion transporter C

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Abcc5 NCBI NCBI:10057