2. Gene
  3. Trpm2 - transient receptor potential cation channel, subfamily M, member 2 Gene

Trpm2 - transient receptor potential cation channel, subfamily M, member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Trp7; TRPC7; Trrp7; LTRPC2; 9830168K16Rik

基因 ID: 28240 | 基因类型: protein coding

关于 Trpm2

功能概要

Enables ligand-gated Calcium Channel activity and manganese ion transmembrane transporter activity. Involved in several processes, including calcium ion transmembrane import into cytosol; calcium-mediated signaling using intracellular calcium source; and cellular response to temperature stimulus. Acts upstream of or within manganese ion transport and response to hydroperoxide. Located in cytoplasmic vesicle membrane; lysosomal membrane; and plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Apr 2022]

Trpm2 基因产物(2)

mRNA Protein Name
NM_001411900.1 NP_001398829.1 transient receptor potential cation channel subfamily M member 2
NM_138301.2 NP_612174.2 transient receptor potential cation channel subfamily M member 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ligand-gated calcium channel activity IMP
IMP: 通过突变表型推断
21753080 MGI
enables manganese ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
11804595 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium ion import across plasma membrane IMP
IMP: 通过突变表型推断
21753080 MGI
involved in cellular response to temperature stimulus IMP
IMP: 通过突变表型推断
27562954 MGI
involved in dendritic cell chemotaxis IMP
IMP: 通过突变表型推断
21753080 MGI
involved in dendritic cell differentiation IMP
IMP: 通过突变表型推断
21753080 MGI
acts upstream of or within manganese ion transport IDA
IDA: 通过直接分析推断
11804595 MGI
involved in release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
21753080 MGI
involved in response to heat IMP
IMP: 通过突变表型推断
27562954 MGI
acts upstream of or within response to hydroperoxide IDA
IDA: 通过直接分析推断
11804595 MGI
involved in temperature homeostasis IMP
IMP: 通过突变表型推断
27562954 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle membrane IDA
IDA: 通过直接分析推断
21753080 MGI
located in lysosomal membrane IDA
IDA: 通过直接分析推断
21753080 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
11804595 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transient receptor potential cation channel subfamily M member 2

LTrpC-2

long transient receptor potential channel 2

transient receptor potential channel 7

transient receptor protein 7

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14600 Rosiglitazone maleate 99.73% 是
HY-14600R Rosiglitazone maleate (Standard) / 否
HY-B0700 Rosiglitazone sodium / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-100973A Adenosine 5′-diphosphoribose sodium 99.47% Phase 1
Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110220 CIM0216 Agonist 99.94% 否
HY-149143 JNJ-28583113 Inhibitor 98.82% 否
HY-101507 Zerencotrep Inhibitor 99.47% 否
HY-113037C Farnesyl pyrophosphate ammonium Agonist ≥95.0% 否
HY-18662 RQ-00203078 Antagonist 99.84% 否
HY-N7395 Cyclic ADP-​ribose Activator ≥96.0% 否
HY-N7395A Cyclic ADP-​ribose ammonium Activator 99.38% 否
HY-113037 (E/Z)-Farnesyl pyrophosphate Agonist / 否
HY-134261 8-Br-ADPR / 否
HY-173449 TRPM2-IN-1 Inhibitor / 否
HY-P5883 TAT-M2NX Inhibitor / 否
HY-RS02848 CLU Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15112 TRPM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-117804 8-Br-cADPR Antagonist / 否
HY-134268 8-Br-7-CH-ADPR Antagonist / 否
HY-137704 2′-Deoxy-ADPR Agonist / 否
HY-RS16755 Trpm2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23194 Trpm2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23774 Clu Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Trpm2 NCBI NCBI:7226
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