TRPM2 - transient receptor potential cation channel subfamily M member 2 Gene

中文名称：瞬时受体电位阳离子通道亚家族 M 成员 2

种属: Homo sapiens

同用名: KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; LTrpC-2; NUDT9L1

基因 ID: 7226 | 基因类型: protein coding

关于 TRPM2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,353,621-44,442,644 (from NCBI)

This gene has 7 transcripts (splice variants), 243 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 4.5), brain (RPKM 2.6) and 21 other tissues.

功能概要

由该基因编码的蛋白质形成一个四聚体阳离子通道，该通道可渗透钙、钠和钾，并受游离的细胞内 ADP-核糖调节。编码的蛋白质被氧化应激激活并赋予对细胞死亡的易感性。可变剪接导致编码不同蛋白质亚型的多个转录变体。已经描述了该基因的其他转录变体，但它们的全长性质尚不清楚。[RefSeq 提供，2016 年 2 月]

The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]

TRPM2 基因产物(4)

mRNA	Protein	Name
NM_001320350.2	NP_001307279.2	transient receptor potential cation channel subfamily M member 2 isoform 2
NM_001320351.2	NP_001307280.2	transient receptor potential cation channel subfamily M member 2 isoform 3
NM_001320352.3	NP_001307281.1	transient receptor potential cation channel subfamily M member 2 isoform 4
NM_003307.4	NP_003298.2	transient receptor potential cation channel subfamily M member 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables ADP-ribose diphosphatase activity	IDA IDA: 通过直接分析推断	30467180	GOA
enables calcium ion binding	IDA IDA: 通过直接分析推断	30467180	GOA
enables calcium ion binding	IMP IMP: 通过突变表型推断	19171771	GOA
NOT enables hydrolase activity	IMP IMP: 通过突变表型推断	27383051	GOA
enables intracellularly gated calcium channel activity	IMP IMP: 通过突变表型推断	27068538	GOA
enables ligand-gated calcium channel activity	IDA IDA: 通过直接分析推断	19171771	GOA
enables mono-ADP-D-ribose binding	IDA IDA: 通过直接分析推断	30467180	GOA
enables monoatomic cation channel activity	IMP IMP: 通过突变表型推断	27068538	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in calcium ion transmembrane import into cytosol	IMP IMP: 通过突变表型推断	19171771	GOA
involved in calcium ion transmembrane transport	IDA IDA: 通过直接分析推断	25620041	GOA
involved in cellular response to calcium ion	IMP IMP: 通过突变表型推断	19171771	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: 通过直接分析推断	27068538	GOA
involved in protein homotetramerization	IDA IDA: 通过直接分析推断	30467180	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: 通过突变表型推断	27068538	GOA
involved in regulation of filopodium assembly	IMP IMP: 通过突变表型推断	27068538	GOA
involved in release of sequestered calcium ion into cytosol	IMP IMP: 通过突变表型推断	27068538	GOA
involved in response to purine-containing compound	IMP IMP: 通过突变表型推断	19171771	GOA
involved in zinc ion transmembrane transport	IMP IMP: 通过突变表型推断	27068538	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in lysosome	IDA IDA: 通过直接分析推断	27068538	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	27333281	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	19171771	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRPM2 蛋白结构

Ion_trans

0
300
600
900
1200
1503 a.a.

蛋白主名

其他名称

transient receptor potential cation channel subfamily M member 2

estrogen-responsive element-associated gene 1 protein

关联疾病

疾病名称

别名

Calcific Tendinitis

Calcific Tendinitis Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	纯度	是否罕见病
HY-14600	Rosiglitazone maleate	99.73%	是
HY-14600R	Rosiglitazone maleate (Standard)	/	否
HY-B0700	Rosiglitazone sodium	/	否

目录号	产品名	作用方式	纯度	Phase
HY-100973A	Adenosine 5′-diphosphoribose sodium		99.47%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-110220	CIM0216	Agonist	99.94%	否
HY-149143	JNJ-28583113	Inhibitor	98.82%	否
HY-101507	Zerencotrep	Inhibitor	99.47%	否
HY-113037C	Farnesyl pyrophosphate ammonium	Agonist	≥95.0%	否
HY-18662	RQ-00203078	Antagonist	99.84%	否
HY-N7395	Cyclic ADP-ribose	Activator	≥96.0%	否
HY-N7395A	Cyclic ADP-ribose ammonium	Activator	99.38%	否
HY-113037	(E/Z)-Farnesyl pyrophosphate	Agonist	/	否
HY-134261	8-Br-ADPR		/	否
HY-173449	TRPM2-IN-1	Inhibitor	/	否
HY-P5883	TAT-M2NX	Inhibitor	/	否
HY-RS02848	CLU Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS15112	TRPM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-117804	8-Br-cADPR	Antagonist	/	否
HY-134268	8-Br-7-CH-ADPR	Antagonist	/	否
HY-137704	2′-Deoxy-ADPR	Agonist	/	否
HY-RS16755	Trpm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23194	Trpm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23774	Clu Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	TRPM2	VGNC	VGNC:36389
Felis catus	TRPM2	VGNC	VGNC:66588
Macaca mulatta	TRPM2	VGNC	VGNC:78655
Mus musculus	TRPM2	MGD	MGI:1351901
Rattus norvegicus	TRPM2	RGD	RGD:1311889

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