1. Gene
  2. TAFA3 - TAFA chemokine like family member 3 Gene

TAFA3 - TAFA chemokine like family member 3 Gene

中文名称:TAFA 趋化因子样家族成员 3

种属: Homo sapiens

同用名: TAFA-3; FAM19A3

基因 ID: 284467 | 基因类型: protein coding

关于 TAFA3

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,718,905-112,727,235 (from NCBI)

This gene has 2 transcripts (splice variants), 383 orthologues and 3 paralogues. Biased expression in adrenal (RPKM 7.0) and testis (RPKM 3.0).

功能概要

该基因是 TAFA 家族的成员,该家族由五个高度同源的基因组成,编码小的分泌蛋白。这些蛋白质在固定位置包含保守的半胱氨酸残基,并且与 CC 趋化因子家族的成员 MIP-1alpha 有远缘关系。 TAFA 蛋白主要在大脑的特定区域表达,并被假定作为大脑特异性趋化因子或神经因子发挥作用,充当免疫和神经细胞的调节剂。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2011 年 11 月]

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

TAFA3 基因产物(2)

mRNA Protein Name
NM_001004440.2 NP_001004440.1 chemokine-like protein TAFA-3 isoform 2 precursor
NM_182759.3 NP_877436.1 chemokine-like protein TAFA-3 isoform 1 precursor
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
25595455 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TAFA3 蛋白结构

TAFA

TAFA: TAFA family (42 - 131)

  • 0
  • 100
  • 133 a.a.
蛋白主名 其他名称

chemokine-like protein TAFA-3

family with sequence similarity 19 (chemokine (C-C motif)-like), member A3

直系同源

种属 基因名 来源 基因 ID
Mus musculus TAFA3 MGD MGI:3046463
Bos taurus TAFA3 VGNC VGNC:106963
Macaca mulatta TAFA3 VGNC VGNC:78190
Rattus norvegicus TAFA3 RGD RGD:1587462
Felis catus TAFA3 VGNC VGNC:82544