2. Gene
  3. TREML4 - triggering receptor expressed on myeloid cells like 4 Gene

TREML4 - triggering receptor expressed on myeloid cells like 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：在骨髓细胞上表达的触发受体样 4

种属: Homo sapiens

同用名: TLT4; TLT-4

基因 ID: 285852 | 基因类型: protein coding

关于 TREML4

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,228,349-41,238,882 (from NCBI)

This gene has 3 transcripts (splice variants), 69 orthologues and 2 paralogues. Low expression observed in reference dataset.

功能概要

预测启用信号受体活动。参与 Toll 样受体 7 信号通路的正调控。预测位于内质网。预计在细胞表面有活性。预测与核内体膜和溶酶体膜共定位。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable signaling receptor activity. Involved in positive regulation of Toll-like Receptor 7 signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface. Predicted to colocalize with endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TREML4 基因产物(1)

mRNA Protein Name
NM_198153.3 NP_937796.1 trem-like transcript 4 protein precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of toll-like receptor 7 signaling pathway IMP
IMP: 通过突变表型推断
25848864 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TREML4 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (18 - 117)

  • 0
  • 100
  • 200 a.a.
蛋白主名 其他名称

trem-like transcript 4 protein

TREM like transcript 4

关联疾病

疾病名称 别名
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15006 TREML4 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TREML4 RGD RGD:1587021
Mus musculus TREML4 MGD MGI:1923239
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