2. Gene
  3. Stub1 - STIP1 homology and U-box containing protein 1 Gene

Stub1 - STIP1 homology and U-box containing protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Chip

基因 ID: 287155 | 基因类型: protein coding

关于 Stub1

功能概要

Enables chaperone binding activity. Involved in several processes, including cellular response to hypoxia; chaperone-mediated autophagy; and response to ischemia. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 16 and cerebellar ataxia type 48. Orthologous to human STUB1 (STIP1 homology and U-box containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Stub1 基因产物(1)

mRNA Protein Name
NM_001025625.2 NP_001020796.2 E3 ubiquitin-protein ligase CHIP
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15671027 RGD
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
20724525 RGD
enables ubiquitin protein ligase activity IMP
IMP: 通过突变表型推断
19237536 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in MAPK cascade IMP
IMP: 通过突变表型推断
20724525 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
30980393 RGD
involved in negative regulation of cardiac muscle hypertrophy IMP
IMP: 通过突变表型推断
30980393 RGD
involved in negative regulation of smooth muscle cell apoptotic process IMP
IMP: 通过突变表型推断
19483080 RGD
involved in negative regulation of vascular associated smooth muscle contraction IMP
IMP: 通过突变表型推断
19237536 RGD
involved in positive regulation of mitophagy IMP
IMP: 通过突变表型推断
29934347 RGD
involved in positive regulation of smooth muscle cell apoptotic process IMP
IMP: 通过突变表型推断
21808025 RGD
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
19237536 RGD
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
19483080 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19237536 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
29934347 RGD
located in nucleus IDA
IDA: 通过直接分析推断
19237536 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase CHIP

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

carboxy terminus of Hsp70-interacting protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13972 STUB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17083 Stub1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23527 Stub1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stub1 NCBI NCBI:10273
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