2. Gene
  3. Per1 - period circadian regulator 1 Gene

Per1 - period circadian regulator 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: rper1

基因 ID: 287422 | 基因类型: protein coding

关于 Per1

功能概要

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. [provided by RefSeq, Jan 2014]

Per1 基因产物(1)

mRNA Protein Name
NM_001034125.1 NP_001029297.1 period circadian protein homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11597585 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in circadian rhythm IEP
IEP: 通过表达模式推断
12176169 RGD
involved in circadian rhythm IMP
IMP: 通过突变表型推断
11122332 RGD
involved in negative regulation of JNK cascade IMP
IMP: 通过突变表型推断
24447840 RGD
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
24447840 RGD
involved in neural retina development IEP
IEP: 通过表达模式推断
20589906 RGD
involved in regulation of cytokine production involved in inflammatory response IMP
IMP: 通过突变表型推断
24447840 RGD
involved in regulation of p38MAPK cascade IMP
IMP: 通过突变表型推断
24447840 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
22356123 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

period circadian protein homolog 1

circadian clock protein PERIOD 1

period 1

period circadian clock 1

period homolog 1

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125145 AA92593 99.94% 否
HY-N10987 Spiranthesol / 否
HY-RS10331 PER1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19930 Per1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26432 Per1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Per1 NCBI NCBI:5187
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