2. Gene
  3. Ncstn - nicastrin Gene

Ncstn - nicastrin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 289231 | 基因类型: protein coding

关于 Ncstn

功能概要

Enables peptidase activity. Involved in cerebellum development and protein processing. Located in several cellular components, including cytoplasmic vesicle; lysosomal membrane; and sarcolemma. Part of protein-containing complex. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Apr 2022]

Ncstn 基因产物(1)

mRNA Protein Name
NM_174864.3 NP_777353.1 nicastrin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidase activity IDA
IDA: 通过直接分析推断
12736250 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15456764 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cerebellum development IEP
IEP: 通过表达模式推断
16298244 RGD
involved in protein processing IEP
IEP: 通过表达模式推断
12736250 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
20126630 RGD
located in lysosomal membrane IDA
IDA: 通过直接分析推断
12736250 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
20126630 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
15456764 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
16595164 RGD
located in synaptic membrane IDA
IDA: 通过直接分析推断
20126630 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
20126630 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nicastrin

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09103 NCSTN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18670 Ncstn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25156 Ncstn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ncstn NCBI NCBI:23385
Mus musculus Ncstn NCBI NCBI:59287
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