2. Gene
  3. Oprk1 - opioid receptor, kappa 1 Gene

Oprk1 - opioid receptor, kappa 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29335 | 基因类型: protein coding

关于 Oprk1

功能概要

This gene encodes an Opioid Receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of Adenylate Cyclase activity and neurotransmitter release. This Opioid Receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Oprk1 基因产物(2)

mRNA Protein Name
NM_001318742.1 NP_001305671.1 kappa-type opioid receptor isoform 1x
NM_017167.3 NP_058863.1 kappa-type opioid receptor isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21041644 RGD
enables receptor serine/threonine kinase binding IPI
IPI: 通过物理相互作用推断
27865836 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to cocaine IMP
IMP: 通过突变表型推断
24919534 RGD
involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
27865836 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
9645969 RGD
involved in conditioned place preference IMP
IMP: 通过突变表型推断
21549821 RGD
involved in eating behavior IMP
IMP: 通过突变表型推断
11961051 RGD
involved in estrous cycle IEP
IEP: 通过表达模式推断
21041644 RGD
involved in maternal behavior IDA
IDA: 通过直接分析推断
22641418 RGD
involved in negative regulation of luteinizing hormone secretion IMP
IMP: 通过突变表型推断
23391862 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
9572309 RGD
involved in positive regulation of dopamine secretion IDA
IDA: 通过直接分析推断
17568430 RGD
involved in positive regulation of eating behavior IMP
IMP: 通过突变表型推断
17456590 RGD
involved in positive regulation of p38MAPK cascade IDA
IDA: 通过直接分析推断
16648139 RGD
involved in positive regulation of potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
12815037 RGD
involved in response to acrylamide IEP
IEP: 通过表达模式推断
22197712 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
9645969 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
8904783 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
9645969 RGD
involved in response to insulin IDA
IDA: 通过直接分析推断
10995763 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
9645969 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
28509375 RGD
involved in sensory perception of temperature stimulus IMP
IMP: 通过突变表型推断
21041644 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in T-tubule IDA
IDA: 通过直接分析推断
26365878 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
17120286 RGD
located in dendrite IDA
IDA: 通过直接分析推断
17120286 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
26365878 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
17120286 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
17120286 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
11746715 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
11746715 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
26365878 RGD
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
26365878 RGD
is active in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
11746715 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

kappa-type opioid receptor

K-OR-1

KOR-1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116163 ML350 / 否
HY-RS09802 OPRK1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21006 Oprk1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27523 Oprk1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Oprk1 NCBI NCBI:4986
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