2. Gene
  3. Men1 - menin 1 Gene

Men1 - menin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: menin

基因 ID: 29417 | 基因类型: protein coding

关于 Men1

功能概要

Enables chromatin binding activity. Involved in several processes, including animal organ development; regulation of epithelial cell proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in endocrine gland Cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Apr 2022]

Men1 基因产物(1)

mRNA Protein Name
NM_019208.3 NP_062081.1 menin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
24157940 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
22166975 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: 通过表达模式推断
21239441 RGD
involved in decidualization IEP
IEP: 通过表达模式推断
19780023 RGD
involved in negative regulation of cell cycle G1/S phase transition IMP
IMP: 通过突变表型推断
15054094 RGD
involved in negative regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
15054094 RGD
involved in negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
15054094 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22120711 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24157940 RGD
involved in regulation of activin receptor signaling pathway IMP
IMP: 通过突变表型推断
15031321 RGD
involved in regulation of type B pancreatic cell proliferation IMP
IMP: 通过突变表型推断
24157940 RGD
involved in response to transforming growth factor beta IMP
IMP: 通过突变表型推断
15054094 RGD
involved in type B pancreatic cell differentiation IMP
IMP: 通过突变表型推断
24157940 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
10612420 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

menin

multiple endocrine neoplasia 1

multiple endocrine neoplasia I

multiple endocrine neoplasia type I

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-151595 Menin-MLL inhibitor-22 Inhibitor 99.85% 否
HY-103304 CGRP antagonist 4 Antagonist / 否
HY-168182 Menin-MLL inhibitor 34 Inhibitor / 否
HY-172416 Balomenib Inhibitor / 否
HY-RS08333 MEN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18140 Men1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24615 Men1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Men1 NCBI NCBI:4221
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