Aire - autoimmune regulator Gene

种属: Rattus norvegicus

关于 Aire

功能概要

Predicted to enable several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including immune system development; positive regulation of macromolecule metabolic process; and regulation of thymocyte migration. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Used to study autoimmune polyendocrine syndrome. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator). [provided by Alliance of Genome Resources, Apr 2022]