2. Gene
  3. XRN1 - Xrn1 5'-3' exoribonuclease 1 Gene

XRN1 - Xrn1 5'-3' exoribonuclease 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: RGD1309713

基因 ID: 300944 | 基因类型: protein coding

关于 XRN1

功能概要

Predicted to enable 5'-3' exoribonuclease activity; G-quadruplex DNA binding activity; and G-quadruplex RNA binding activity. Involved in cellular response to organonitrogen compound; negative regulation of translation; and response to testosterone. Located in several cellular components, including P-body; dendrite; and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human XRN1 (5'-3' exoribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

XRN1 基因产物(1)

mRNA Protein Name
NM_001305240.1 NP_001292169.1 5'-3' exoribonuclease 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cycloheximide IEP
IEP: 通过表达模式推断
25797256 RGD
involved in cellular response to puromycin IEP
IEP: 通过表达模式推断
25736288 RGD
involved in negative regulation of translation IMP
IMP: 通过突变表型推断
25797256 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
25797256 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
22590546 RGD
located in dendrite IDA
IDA: 通过直接分析推断
25797256 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
25797256 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

5'-3' exoribonuclease 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-173593 Adenosine-3',5'-bisphosphate Inhibitor / 否
HY-RS15902 XRN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21461 Xrn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27979 Xrn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens XRN1 NCBI NCBI:54464
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