2. Gene
  3. KAT2B - lysine acetyltransferase 2B Gene

KAT2B - lysine acetyltransferase 2B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：赖氨酸乙酰转移酶2B

种属: Rattus norvegicus

同用名: Pcaf; AABR07066180.1

基因 ID: 301164 | 基因类型: protein coding

关于 KAT2B

Primary_assembly 9: 6,562,288-6,667,064 forward strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 226 orthologues, 11 paralogues and is associated with 4 phenotypes. Biased expression in Muscle (RPKM 351.2), Heart (RPKM 315.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动染色质结合活性；组蛋白乙酰转移酶结合活性；和组蛋白脱乙酰酶结合活性。参与多个过程，包括对甲状旁腺激素刺激的细胞反应；染色质结合活性的正调控；和组蛋白乙酰化的正调控。位于染色质；胞质溶胶；和核。与人 KAT2B（赖氨酸乙酰转移酶 2B）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity; Histone Acetyltransferase binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; positive regulation of chromatin binding activity; and positive regulation of histone acetylation. Located in chromatin; cytosol; and nucleus. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]

KAT2B 基因产物(5)

mRNA Protein Name
XM_039084397.1 XP_038940325.1 histone acetyltransferase KAT2B isoform X2
XM_039084398.1 XP_038940326.1 histone acetyltransferase KAT2B isoform X3
XM_039084400.1 XP_038940328.1 histone acetyltransferase KAT2B isoform X5
XM_039084399.1 XP_038940327.1 histone acetyltransferase KAT2B isoform X4
XM_039084396.1 XP_038940324.1 histone acetyltransferase KAT2B isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
20870727 RGD
enables histone acetyltransferase binding IPI
IPI: 通过物理相互作用推断
20870727 RGD
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
24526703 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
18042454 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IEP
IEP: 通过表达模式推断
18945670 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: 通过表达模式推断
20870727 RGD
involved in memory IEP
IEP: 通过表达模式推断
20811339 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
20094059 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20870727 RGD
involved in protein acetylation IMP
IMP: 通过突变表型推断
22859492 RGD
involved in vasodilation IDA
IDA: 通过直接分析推断
22859492 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
20870727 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KAT2B 蛋白结构

PCAF_N

PCAF_N: pfam06466 (55 - 306)

COG5076

COG5076: cl34891 (467 - 806)

Bromo_gcn5_like

Bromo_gcn5_like: cd05509 (707 - 806)

  • 0
  • 200
  • 400
  • 600
  • 813 a.a.
蛋白主名 其他名称

histone acetyltransferase KAT2B

K(lysine) acetyltransferase 2B

p300/CBP-associated factor

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W015239 KAT8-IN-1 99.40% 否
HY-173158 AUR1545 Inhibitor / 否
HY-168428 CHI-KAT8i5 98.00% 否
HY-RS07077 KAT2B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07078 Kat2b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07079 KAT2B Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens KAT2B NCBI NCBI:8850
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