2. Gene
  3. Disc1 - DISC1 scaffold protein Gene

Disc1 - DISC1 scaffold protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 307940 | 基因类型: protein coding

关于 Disc1

功能概要

Enables Kinesin binding activity. Involved in several processes, including positive regulation of cell projection organization; protein localization to centrosome; and pyramidal neuron migration to cerebral cortex. Acts upstream of or within regulation of glutamatergic synaptic transmission. Located in several cellular components, including central region of growth cone; microtubule cytoskeleton; and perinuclear region of cytoplasm. Part of dynein complex and Kinesin complex. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Orthologous to human DISC1 (DISC1 scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]

Disc1 基因产物(1)

mRNA Protein Name
NM_175596.3 NP_783186.2 disrupted in schizophrenia 1 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinesin binding IDA
IDA: 通过直接分析推断
17202468 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17035248 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
16299498 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
17202468 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cilium assembly IMP
IMP: 通过突变表型推断
20531939 RGD
involved in nervous system development IMP
IMP: 通过突变表型推断
12506198 RGD
involved in positive regulation of axon extension IMP
IMP: 通过突变表型推断
17202468 RGD
involved in positive regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
20479754 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
16299498 RGD
involved in protein localization to centrosome IGI
IGI: 通过遗传相互作用推断
18762586 RGD
involved in protein localization to centrosome IMP
IMP: 通过突变表型推断
18762586 RGD
involved in pyramidal neuron migration to cerebral cortex IMP
IMP: 通过突变表型推断
16299498 RGD
involved in regulation of dendritic spine development IMP
IMP: 通过突变表型推断
20139976 RGD
involved in regulation of neuron projection development IMP
IMP: 通过突变表型推断
17035248 RGD
acts upstream of or within regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
24706880 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
19499587 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
17202468 RGD
located in cell body IDA
IDA: 通过直接分析推断
17202468 RGD
located in central region of growth cone IDA
IDA: 通过直接分析推断
17202468 RGD
located in centrosome IDA
IDA: 通过直接分析推断
16299498 RGD
part of dynein complex IDA
IDA: 通过直接分析推断
16299498 RGD
part of kinesin complex IDA
IDA: 通过直接分析推断
17202468 RGD
located in microtubule IDA
IDA: 通过直接分析推断
17202468 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
17418909 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

disrupted in schizophrenia 1 homolog

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108909 Chymopapain / 否
HY-121003 Aspyrone / 否
HY-RS03781 DISC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21555 Disc1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28073 Disc1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Disc1 NCBI NCBI:27185
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