2. Gene
  3. Atg7 - autophagy related 7 Gene

Atg7 - autophagy related 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Apg7l

基因 ID: 312647 | 基因类型: protein coding

关于 Atg7

功能概要

Predicted to enable Atg12 activating enzyme activity; Atg8 activating enzyme activity; and protein homodimerization activity. Involved in several processes, including cellular response to morphine; negative regulation of mitochondrial DNA replication; and negative regulation of oxidative stress-induced neuron death. Located in axon. Used to study high grade glioma. Biomarker of hypertension; myocardial infarction; neurodegenerative disease; and paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive cerebellar ataxia. Orthologous to human Atg7 (Autophagy related 7). [provided by Alliance of Genome Resources, Apr 2022]

Atg7 基因产物(1)

mRNA Protein Name
NM_001012097.1 NP_001012097.1 ubiquitin-like modifier-activating enzyme ATG7
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to morphine IEP
IEP: 通过表达模式推断
23800874 RGD
involved in cellular response to sodium arsenite IMP
IMP: 通过突变表型推断
25639566 RGD
involved in chaperone-mediated autophagy IMP
IMP: 通过突变表型推断
23434281 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
25241190 RGD
involved in negative regulation of mitochondrial DNA replication IMP
IMP: 通过突变表型推断
23800874 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
23800795 RGD
involved in positive regulation of autophagy IDA
IDA: 通过直接分析推断
24674959 RGD
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
25639566 RGD
involved in positive regulation of programmed cell death IMP
IMP: 通过突变表型推断
25639566 RGD
involved in response to alcohol IEP
IEP: 通过表达模式推断
24226028 RGD
involved in response to fluoride IEP
IEP: 通过表达模式推断
24296261 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
21384092 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
17665967 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
25040536 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ubiquitin-like modifier-activating enzyme ATG7

ATG12-activating enzyme E1 ATG7

ATG7 autophagy related 7 homolog

autophagy 7-like

autophagy related 7 homolog

autophagy-related protein 7

ubiquitin-activating enzyme E1-like protein

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N0538 Xylitol Activator ≥98.0% 是
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-146130 ATG7-IN-2 99.22% 否
HY-145371 ATG7-IN-1 Inhibitor 99.91% 否
HY-146131 ATG7-IN-3 99.26% 否
HY-173133 Antitumor agent-199 Activator / 否
HY-W768347 Xylitol-13C5 / 否
HY-170594 Antitumor agent-192 / 否
HY-151914 Antitumor agent-82 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atg7 NCBI NCBI:10533
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