2. Gene
  3. Abca1 - ATP binding cassette subfamily A member 1 Gene

Abca1 - ATP binding cassette subfamily A member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 313210 | 基因类型: protein coding

关于 Abca1

功能概要

Enables ATPase-coupled transmembrane transporter activity and high-density lipoprotein particle binding activity. Involved in several processes, including cellular response to cholesterol; lipid transport; and lipoprotein biosynthetic process. Located in basolateral plasma membrane and cell surface. Biomarker of several diseases, including extrahepatic cholestasis; fatty liver disease; membranous glomerulonephritis; obesity; and premature menopause. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hypolipoproteinemia (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human ABCA1 (ATP binding cassette subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Abca1 基因产物(1)

mRNA Protein Name
NM_178095.3 NP_835196.2 phospholipid-transporting ATPase ABCA1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase-coupled transmembrane transporter activity IDA
IDA: 通过直接分析推断
12909583 RGD
enables high-density lipoprotein particle binding IDA
IDA: 通过直接分析推断
15907796 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cholesterol IEP
IEP: 通过表达模式推断
15907796 RGD
involved in cellular response to cytokine stimulus IEP
IEP: 通过表达模式推断
25445438 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
21554872 RGD
involved in cholesterol transport IDA
IDA: 通过直接分析推断
12909583 RGD
involved in cholesterol transport IMP
IMP: 通过突变表型推断
14993246 RGD
involved in lipoprotein biosynthetic process IEP
IEP: 通过表达模式推断
21554872 RGD
involved in lipoprotein biosynthetic process IMP
IMP: 通过突变表型推断
14993246 RGD
involved in phospholipid transport IDA
IDA: 通过直接分析推断
12909583 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
15710224 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
25612518 RGD
involved in response to vitamin B3 IEP
IEP: 通过表达模式推断
19878707 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
14690017 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
28660384 RGD
located in cell surface IDA
IDA: 通过直接分析推断
15907796 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

phospholipid-transporting ATPase ABCA1

ATP-binding cassette sub-family A member 1

ATP-binding cassette, sub-family A (ABC1), member 1

ATP-binding cassette, subfamily A (ABC1), member 1

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0388 Probucol 99.97% 是
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-134377 Bocidelpar Modulator 98.08% Phase 2
HY-P6306A CS-6253 TFA 98.53% Phase 1
Pre-clinical Phase
生物活性分子 (24)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-D0086 DIDS sodium salt Inhibitor 99.13% 否
HY-18282 AZ876 Agonist 99.77% 否
HY-123402 GSK3987 Agonist 99.19% 否
HY-N2419 Erythrodiol 99.75% 否
HY-P6306 CS-6253 98.84% 否
HY-N0686 Pseudoprotodioscin Inhibitor 98.76% 否
HY-123148 IMB-808 Agonist 99.85% 否
HY-117006 E1231 Activator 98.55% 否
HY-141645 IMM-H007 97.07% 否
HY-N0364 Falcarindiol 99.48% 否
HY-143200 OSBPL7-IN-1 Inhibitor 99.79% 否
HY-122936 Tanshindiol C 98.47% 否
HY-RS00037 ABCA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-121671 TBTC Activator / 否
HY-121693 DIDS Inhibitor / 否
HY-169080 ABCA1 inducer 1 Inducer / 否
HY-170570 PFM046 / 否
HY-173230 ABCA1 inducer 2 / 否
HY-N13361 Elodeoidileon A Agonist / 否
HY-W201317 E17241 Agonist / 否
HY-W674245 10-Hydroxyhexadecanoic acid / 否
HY-RS16554 Abca1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22987 Abca1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W590664 C2 Dihydroceramide / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Abca1 NCBI NCBI:19
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