FOXA1 - forkhead box A1 Gene

中文名称：叉头盒 A1

种属: Homo sapiens

同用名: HNF3A; TCF3A

基因 ID: 3169 | 基因类型: protein coding

关于 FOXA1

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:37,589,552-37,595,249 (from NCBI)

This gene has 5 transcripts (splice variants), 147 orthologues, 42 paralogues and is associated with 71 phenotypes. Biased expression in prostate (RPKM 46.5), urinary bladder (RPKM 12.0) and 6 other tissues.

功能概要

该基因编码叉头类 DNA 结合蛋白的一个成员。这些肝细胞核因子是肝脏特异性转录物 (如白蛋白和转甲状腺素蛋白) 的转录激活因子，它们还与染色质相互作用。小鼠中的相似家族成员在代谢调节以及胰腺和肝脏的分化中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]

FOXA1 基因产物(1)

mRNA	Protein	Name
NM_004496.5	NP_004487.2	hepatocyte nuclear factor 3-alpha

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	9931457	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	25802280	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	22722839	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	16087863	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	20160041	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	16087863	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	19127412	GOA
involved in positive regulation of intracellular estrogen receptor signaling pathway	IMP IMP: 通过突变表型推断	16087863	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: 通过突变表型推断	16087863	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16331276	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16087863	GOA
involved in response to estradiol	IDA IDA: 通过直接分析推断	16087863	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	9931457	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXA1 蛋白结构

Forkhead_N

Forkhead

HNF_C

0
100
200
300
400
472 a.a.

蛋白主名

其他名称

hepatocyte nuclear factor 3-alpha

HNF-3-alpha

FOXA1 抗体

目录号	产品名	应用	反应物种
HY-P81357	FOXA1 Antibody (YA1102)	IHC-P	Human
HY-P86243	HNF-3α Antibody (YA5935)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

关联疾病

疾病名称

别名

Miliaria Profunda

Icd10cm:L74.2

Snomedct_us_2020_03_01:47317002

Apocrine Sweat Gland Neoplasm

Apocrine Tumor

Apocrine Neoplasm

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Breast Lobular Carcinoma

Cancer, Breast, Lobular

Lobular Breast Carcinoma

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Estrogen-Receptor Negative Breast Cancer

Estrogen-Receptor Positive Breast Cancer

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Colon Leiomyoma

Colonic Leiomyoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-156190A	NR2F2-IN-1 free base	Inhibitor	99.34%	否
HY-RS05036	FOXA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-168534	WX-02-23		99.88%	否
HY-156190	NR2F2-IN-1	Inhibitor	/	否
HY-RS17339	Foxa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23794	Foxa1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	FOXA1	VGNC	VGNC:53490
Rattus norvegicus	FOXA1	RGD	RGD:2807
Mus musculus	FOXA1	MGD	MGI:1347472
Bos taurus	FOXA1	VGNC	VGNC:29077
Macaca mulatta	FOXA1	VGNC	VGNC:72707
Felis catus	FOXA1	VGNC	VGNC:67600

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FOXA1 - forkhead box A1 Gene

关于 FOXA1

功能概要

FOXA1 基因产物(1)

FOXA1 蛋白结构

FOXA1 抗体

关联疾病

直系同源

热门区域

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FOXA1 - forkhead box A1 Gene

关于 FOXA1

功能概要

FOXA1 基因产物(1)

FOXA1 蛋白结构

FOXA1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z