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  2. HOXB3 - homeobox B3 Gene

HOXB3 - homeobox B3 Gene

中文名称:同源框 B3

种属: Homo sapiens

同用名: HOX2; HOX2G; Hox-2.7

基因 ID: 3213 | 基因类型: protein coding

关于 HOXB3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,548,870-48,590,241 (from NCBI)

This gene has 13 transcripts (splice variants), 187 orthologues and 42 paralogues. Broad expression in kidney (RPKM 1.6), fat (RPKM 1.3) and 21 other tissues.

功能概要

该基因是 Antp 同源框家族的成员,编码具有同源框 DNA 结合域的核蛋白。它包含在位于 17 号染色体上的同源框 B 基因簇中。编码的蛋白质作为参与发育的序列特异性转录因子发挥作用。该基因的表达增加与急性髓性白血病 (AML) 的一个独特的生物学亚群相关。[RefSeq 提供,2008 年 7 月]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]

HOXB3 基因产物(6)

mRNA Protein Name
NM_001330322.2 NP_001317251.1 homeobox protein Hox-B3 isoform 2
NM_001330323.1 NP_001317252.1 homeobox protein Hox-B3 isoform 3
NM_001384747.1 NP_001371676.1 homeobox protein Hox-B3 isoform 1
NM_001384749.1 NP_001371678.1 homeobox protein Hox-B3 isoform 1
NM_001384750.1 NP_001371679.1 homeobox protein Hox-B3 isoform 2
NM_002146.4 NP_002137.4 homeobox protein Hox-B3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
9556594 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7913891 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IEP
IEP: 通过表达模式推断
17972163 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9556594 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HOXB3 蛋白结构

Homeobox

Homeobox: Homeobox domain (189 - 245)

DUF4074

DUF4074: Domain of unknown function (DUF4074) (364 - 429)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
蛋白主名 其他名称

homeobox protein Hox-B3

homeo box 2G

直系同源

种属 基因名 来源 基因 ID
Bos taurus HOXB3 VGNC VGNC:29919
Felis catus HOXB3 VGNC VGNC:67623
Rattus norvegicus HOXB3 RGD RGD:1310780
Mus musculus HOXB3 MGD MGI:96184
Canis familiaris HOXB3 VGNC VGNC:41751