AGFG2 - ArfGAP with FG repeats 2 Gene

中文名称：ArfGAP 与 FG 重复 2

种属: Homo sapiens

同用名: HRBL; RABR

关于 AGFG2

功能概要

该基因是 HIV-1 Rev 结合蛋白 (HRB) 家族的一员，编码的蛋白质具有一个 Arf-GAP 锌指结构域、多个 phe-gly (FG) 基序和四个 asn-pro-phe (NPF) 基序.这种蛋白质与 Eps15 同源 (EH) 结构域相互作用，并在 Rev 输出通路中发挥作用，该通路介导蛋白质和 RNA 的核质转移。已经描述了选择性剪接的转录本变体，但尚未确定它们的生物学有效性。[RefSeq 提供，2013 年 2 月]

This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]