1. Gene
  2. ID4 - inhibitor of DNA binding 4 Gene

ID4 - inhibitor of DNA binding 4 Gene

中文名称:DNA 结合抑制因子 4

种属: Homo sapiens

同用名: IDB4; bHLHb27

基因 ID: 3400 | 基因类型: protein coding

关于 ID4

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:19,837,370-19,842,197 (from NCBI)

This gene has 1 transcript (splice variant), 176 orthologues and 3 paralogues. Biased expression in thyroid (RPKM 167.8), brain (RPKM 37.5) and 12 other tissues.

功能概要

该基因编码 DNA 结合抑制剂 (ID) 蛋白家族的成员。编码的蛋白质缺乏 DNA 结合能力,而是通过结合和抑制基本的螺旋-环-螺旋转录因子来调节基因表达。这种蛋白质与在发育和肿瘤发生中起作用的多种细胞过程的调节有关。[RefSeq 提供,2017 年 8 月]

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis. [provided by RefSeq, Aug 2017]

ID4 基因产物(1)

mRNA Protein Name
NM_001546.4 NP_001537.1 DNA-binding protein inhibitor ID-4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
enables transcription regulator inhibitor activity IDA
IDA: 通过直接分析推断
7665172 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11136250 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7665172 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ID4 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (67 - 105)

  • 0
  • 100
  • 161 a.a.
蛋白主名 其他名称

DNA-binding protein inhibitor ID-4

class B basic helix-loop-helix protein 27

ID4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ID4 P47928 NCK1 Homo sapiens P16333 17474147
种属内
ID4 P47928 SPRED1 Homo sapiens Q7Z699 32814053
种属内
ID4 P47928 SPRED1 Homo sapiens Q7Z699 32814053
种属内
ID4 P47928 SPRED1 Homo sapiens Q7Z699 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mesomelic Dysplasia, Savarirayan Type

Mesomelic Dysplasia With Absent Fibulas And Triangular Tibias

Mesomelic Dysplasia Savarirayan Type

Triangular Tibia And Fibular Aplasia

Triangular Tibia-Fibular Aplasia Syndrome

Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant

Sporadic Breast Cancer

Sporadic Breast Carcinoma

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ID4 VGNC VGNC:73557
Felis catus ID4 VGNC VGNC:102441
Bos taurus ID4 VGNC VGNC:106777
Mus musculus ID4 MGD MGI:99414
Rattus norvegicus ID4 RGD RGD:631428
Macaca fascicularis ID4 NCBI NCBI:102139121
Others ID4 NCBI