ID4 - inhibitor of DNA binding 4 Gene

中文名称：DNA 结合抑制因子 4

种属: Homo sapiens

同用名: IDB4; bHLHb27

基因 ID: 3400 | 基因类型: protein coding

关于 ID4

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:19,837,370-19,842,197 (from NCBI)

This gene has 1 transcript (splice variant), 176 orthologues and 3 paralogues. Biased expression in thyroid (RPKM 167.8), brain (RPKM 37.5) and 12 other tissues.

功能概要

该基因编码 DNA 结合抑制剂 (ID) 蛋白家族的成员。编码的蛋白质缺乏 DNA 结合能力，而是通过结合和抑制基本的螺旋-环-螺旋转录因子来调节基因表达。这种蛋白质与在发育和肿瘤发生中起作用的多种细胞过程的调节有关。[RefSeq 提供，2017 年 8 月]

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis. [provided by RefSeq, Aug 2017]

ID4 基因产物(1)

mRNA	Protein	Name
NM_001546.4	NP_001537.1	DNA-binding protein inhibitor ID-4

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17474147	GOA
enables transcription regulator inhibitor activity	IDA IDA: 通过直接分析推断	7665172	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11136250	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7665172	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ID4 蛋白结构

HLH

0
100
161 a.a.

蛋白主名

其他名称

DNA-binding protein inhibitor ID-4

class B basic helix-loop-helix protein 27

ID4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ID4	P47928	NCK1	Homo sapiens	P16333	Peptide Array	17474147
种属内	ID4	P47928	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	ID4	P47928	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	ID4	P47928	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mesomelic Dysplasia, Savarirayan Type

Mesomelic Dysplasia With Absent Fibulas And Triangular Tibias	Mesomelic Dysplasia Savarirayan Type
Triangular Tibia And Fibular Aplasia	Triangular Tibia-Fibular Aplasia Syndrome

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Sporadic Breast Cancer

Sporadic Breast Carcinoma

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06525	ID4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17871	Id4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24340	Id4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ID4	VGNC	VGNC:73557
Felis catus	ID4	VGNC	VGNC:102441
Bos taurus	ID4	VGNC	VGNC:106777
Mus musculus	ID4	MGD	MGI:99414
Rattus norvegicus	ID4	RGD	RGD:631428
Macaca fascicularis	ID4	NCBI	NCBI:102139121
Others	ID4	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ID4 - inhibitor of DNA binding 4 Gene

关于 ID4

功能概要

ID4 基因产物(1)

ID4 蛋白结构

ID4 蛋白互作信息

关联疾病

直系同源

热门区域

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ID4 - inhibitor of DNA binding 4 Gene

关于 ID4

功能概要

ID4 基因产物(1)

ID4 蛋白结构

ID4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z