2. Gene
  3. ING2 - inhibitor of growth family member 2 Gene

ING2 - inhibitor of growth family member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：生长抑制因子 2

种属: Homo sapiens

同用名: ING1L; p33ING2

基因 ID: 3622 | 基因类型: protein coding

关于 ING2

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:183,505,058-183,512,429 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 10.5), adrenal (RPKM 8.4) and 25 other tissues.

功能概要

该基因是生长抑制剂 (ING) 家族的成员。 ING 家族成员与组蛋白乙酰转移酶 (HAT) 和组蛋白脱乙酰酶 (HDAC) 复合物相关并调节其活性，并在 DNA 修复和细胞凋亡中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 5 月]

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of Histone Acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

ING2 基因产物(2)

mRNA Protein Name
NM_001291959.2 NP_001278888.1 inhibitor of growth protein 2 isoform 2
NM_001564.4 NP_001555.1 inhibitor of growth protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15243141 GOA
enables methylated histone binding IDA
IDA: 通过直接分析推断
16728974 GOA
enables phosphatidylinositol binding IDA
IDA: 通过直接分析推断
16893883 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18334480 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
18334480 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18334480 GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
18334480 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15243141 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CCAAT-binding factor complex IDA
IDA: 通过直接分析推断
15243141 GOA
part of Sin3-type complex IDA
IDA: 通过直接分析推断
16387653 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15243141 GOA
located in nucleus IMP
IMP: 通过突变表型推断
25578879 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
25578879 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ING2 蛋白结构

ING

ING: Inhibitor of growth proteins N-terminal histone-binding (27 - 124)

PHD

PHD: PHD-finger (214 - 259)

  • 0
  • 100
  • 200
  • 280 a.a.
蛋白主名 其他名称

inhibitor of growth protein 2

ING1Lp

ING2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ING2 Q9H160 SIN3A Homo sapiens Q96ST3
Anti Tag CoIP
33961781
种属内
ING2 Q9H160 SIN3A Homo sapiens Q96ST3
Anti Bait CoIP
20676127
种属内
ING2 Q9H160 SIN3A Homo sapiens Q96ST3
Anti Tag CoIP
28514442
种属内
ING2 Q9H160 PCNA Homo sapiens P12004
Anti Bait CoIP
19730436
种属内
ING2 Q9H160 PCNA Homo sapiens P12004
Pull Down
19730436
种属内
ING2 Q9H160 SMURF1 Homo sapiens Q9HCE7-2
Pull Down
20621832
种属内
ING2 Q9H160 SMURF1 Homo sapiens Q9HCE7-2
Anti Tag CoIP
20621832
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06808 ING2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06809 ING3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ING2 VGNC VGNC:30195
Canis familiaris ING2 VGNC VGNC:42017
Mus musculus ING2 MGD MGI:1916510
Felis catus ING2 VGNC VGNC:67803
Macaca mulatta ING2 VGNC VGNC:73743
Rattus norvegicus ING2 RGD RGD:1307347
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z