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  2. Ripk2 - receptor-interacting serine-threonine kinase 2 Gene

Ripk2 - receptor-interacting serine-threonine kinase 2 Gene

中文名称:受体相互作用的丝氨酸-苏氨酸激酶 2

种属: Rattus norvegicus

基因 ID: 362491 | 基因类型: protein coding

关于 Ripk2

Primary_assembly 5: 29,631,570-29,662,657 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 207 orthologues, 23 paralogues and is associated with 1 phenotype. Biased expression in Heart (RPKM 72.), Spleen (RPKM 64.7) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能,包括 JUN 激酶激酶激酶活性;半胱天冬酶结合活性;和蛋白质结构域特异性结合活性。预计参与多个过程,包括细胞对胞壁酰二肽的反应;细胞蛋白质代谢过程的正向调节;和 IL-1 β 产生的正向调节。预计在几个过程的上游或内部起作用,包括免疫反应调节信号通路;细胞因子产生的正调节;和对细菌的反应。预测位于细胞骨架中;胞质溶胶;和囊泡。预计是含蛋白质复合物的一部分。与人 RIPK2(受体相互作用的丝氨酸/苏氨酸激酶 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including JUN kinase kinase kinase activity; Caspase binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including cellular response to muramyl dipeptide; positive regulation of cellular protein metabolic process; and positive regulation of interleukin-1 beta production. Predicted to act upstream of or within several processes, including immune response-regulating signaling pathway; positive regulation of cytokine production; and response to bacterium. Predicted to be located in cytoskeleton; cytosol; and vesicle. Predicted to be part of protein-containing complex. Orthologous to human RIPK2 (receptor interacting serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ripk2 基因产物(2)

mRNA Protein Name
NM_001191865.1 NP_001178794.1 receptor-interacting serine/threonine-protein kinase 2
NM_001191865.1 NP_001178794.1 receptor-interacting serine/threonine-protein kinase 2

Ripk2 蛋白结构

STKc_RIP2

STKc_RIP2: cd14026 (19 - 302)

CARD_RIP2_CARD3

CARD_RIP2_CARD3: cd08786 (436 - 522)

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  • 539 a.a.
蛋白主名 其他名称

receptor-interacting serine/threonine-protein kinase 2

receptor (TNFRSF)-interacting serine-threonine kinase 2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ripk2 NCBI NCBI:8767