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  3. RAB15 - RAB15, member RAS oncogene family Gene

RAB15 - RAB15, member RAS oncogene family Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAB15，RAS 致癌基因家族成员

种属: Homo sapiens

基因 ID: 376267 | 基因类型: protein coding

关于 RAB15

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,945,816-64,972,336 (from NCBI)

This gene has 10 transcripts (splice variants), 264 orthologues and 68 paralogues. Broad expression in brain (RPKM 21.8), urinary bladder (RPKM 12.3) and 21 other tissues.

功能概要

预测启用 GTP 结合活动和 GTPase 活动。参与调节分泌途径的正调节。位于纤毛；内体膜；和细胞质的核周区。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTP binding activity and GTPase activity. Involved in positive regulation of regulated secretory pathway. Located in cilium; endosome membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RAB15 基因产物(3)

mRNA Protein Name
NM_001308154.2 NP_001295083.1 ras-related protein Rab-15 isoform 2
NM_001330182.2 NP_001317111.1 ras-related protein Rab-15 isoform 3
NM_198686.3 NP_941959.1 ras-related protein Rab-15 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16195351 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of regulated secretory pathway IGI
IGI: 通过遗传相互作用推断
22899725 GOA
involved in positive regulation of regulated secretory pathway IMP
IMP: 通过突变表型推断
22899725 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cilium IDA
IDA: 通过直接分析推断
17646400 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16195351 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
16195351 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16195351 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB15 蛋白结构

Ras

Ras: Ras family (10 - 170)

  • 0
  • 100
  • 200
  • 212 a.a.
蛋白主名 其他名称

ras-related protein Rab-15

RAB15, member RAS onocogene family

关联疾病

疾病名称 别名
Immunodeficiency 54

Natural Killer Cell Deficiency, Familial Isolated

Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency

IMD54

Nkcd

Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect

Nkgcd

Familial Isolated Natural Killer Cell Deficiency

Primary Immunodeficiency Due To Mcm4 Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11524 RAB15 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RAB15 RGD RGD:735172
Mus musculus RAB15 MGD MGI:1916865
Bos taurus RAB15 VGNC VGNC:33623
Macaca mulatta RAB15 VGNC VGNC:81519
Canis familiaris RAB15 VGNC VGNC:45255
Felis catus RAB15 VGNC VGNC:104611
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