2. Gene
  3. CLEC12B - C-type lectin domain family 12 member B Gene

CLEC12B - C-type lectin domain family 12 member B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：C 型凝集素结构域家族 12 成员 B

种属: Homo sapiens

同用名: UNQ5782

基因 ID: 387837 | 基因类型: protein coding

关于 CLEC12B

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,006,209-10,018,800 (from NCBI)

This gene has 5 transcripts (splice variants), 351 orthologues and 23 paralogues. Biased expression in testis (RPKM 8.0), skin (RPKM 1.6) and 1 other tissue.

功能概要

启用蛋白磷酸酶结合活性和信号受体抑制剂活性。参与自然杀伤细胞抑制信号通路；自然杀伤细胞介导的细胞毒性的负调节；信号受体活性的负调节。位于质膜外侧。部分含蛋白质复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein Phosphatase binding activity and signaling receptor inhibitor activity. Involved in natural killer cell inhibitory signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; and negative regulation of signaling receptor activity. Located in external side of plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

CLEC12B 基因产物(5)

mRNA Protein Name
NM_001129998.3 NP_001123470.1 C-type lectin domain family 12 member B isoform 1
NM_001319241.1 NP_001306170.1 C-type lectin domain family 12 member B isoform 3
NM_001319242.1 NP_001306171.1 C-type lectin domain family 12 member B isoform 4
NM_001387138.1 NP_001374067.1 C-type lectin domain family 12 member B isoform 5
NM_205852.3 NP_995324.2 C-type lectin domain family 12 member B isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein phosphatase binding IDA
IDA: 通过直接分析推断
34310951 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
17562706 GOA
enables signaling receptor inhibitor activity IMP
IMP: 通过突变表型推断
17562706 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in melanocyte proliferation IDA
IDA: 通过直接分析推断
34310951 GOA
involved in natural killer cell inhibitory signaling pathway IMP
IMP: 通过突变表型推断
17562706 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
17562706 GOA
involved in negative regulation of receptor signaling pathway via STAT IDA
IDA: 通过直接分析推断
34310951 GOA
involved in negative regulation of signaling receptor activity IMP
IMP: 通过突变表型推断
17562706 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IMP
IMP: 通过突变表型推断
17562706 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
17562706 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLEC12B 蛋白结构

Ly49

Ly49: Ly49-like protein, N-terminal region (38 - 157)

Lectin_C

Lectin_C: Lectin C-type domain (162 - 265)

  • 0
  • 100
  • 200
  • 276 a.a.
蛋白主名 其他名称

C-type lectin domain family 12 member B

macrophage antigen h

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02782 CLEC12B Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CLEC12B MGD MGI:1918433
Macaca mulatta CLEC12B VGNC VGNC:71378
Felis catus CLEC12B VGNC VGNC:60942
Rattus norvegicus CLEC12B RGD RGD:1560487
Canis familiaris CLEC12B VGNC VGNC:39326
Bos taurus CLEC12B VGNC VGNC:27424
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