LIN28B - lin-28 homolog B Gene

中文名称：lin-28 同系物 B

种属: Homo sapiens

同用名: CSDD2

基因 ID: 389421 | 基因类型: protein coding

关于 LIN28B

Cytogenetic location: 6q16.3-q21 Genomic coordinates (GRCh38): 6:104,937,026-105,083,332 (from NCBI)

This gene has 3 transcripts (splice variants), 231 orthologues, 4 paralogues and is associated with 1 phenotype. Restricted expression toward placenta (RPKM 24.7).

功能概要

该基因编码的蛋白属于 lin-28 家族，其特征是存在冷休克结构域和一对 CCHC 锌指结构域。该基因在睾丸、胎儿肝脏、胎盘以及原发性人类肿瘤和癌细胞系中高度表达。它受到靶向 3' UTR 位点的 MicroRNA 的负调控，并且该基因在原发性肿瘤中的过表达与 let-7 MicroRNA 家族的抑制和 let-7 靶标的去阻遏有关，从而促进细胞转化。[RefSeq 提供，2012 年 6 月]

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and Cancer cell lines. It is negatively regulated by MicroRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of MicroRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

LIN28B 基因产物(2)

mRNA	Protein	Name
NM_001004317.4	NP_001004317.1	protein lin-28 homolog B isoform 1
NM_001410939.1	NP_001397868.1	protein lin-28 homolog B isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IDA IDA: 通过直接分析推断	19703396	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19703396	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in RNA 3'-end processing	IMP IMP: 通过突变表型推断	19703396	GOA
involved in RNA destabilization	IDA IDA: 通过直接分析推断	18951094	GOA
involved in miRNA catabolic process	IMP IMP: 通过突变表型推断	19703396	GOA
involved in negative regulation of pre-miRNA processing	IDA IDA: 通过直接分析推断	18951094	GOA
involved in negative regulation of primary miRNA processing	IDA IDA: 通过直接分析推断	18951094	GOA
involved in positive regulation of miRNA catabolic process	IMP IMP: 通过突变表型推断	18951094	GOA
involved in pre-miRNA processing	IMP IMP: 通过突变表型推断	19703396	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LIN28B 蛋白结构

CSD

zf-CCHC

0
100
200
250 a.a.

蛋白主名

其他名称

protein lin-28 homolog B

Lin-28.2

LIN28B 抗体

目录号	产品名	应用	反应物种
HY-P80211	Lin28B Antibody (YA709)	WB, ICC/IF, IHC-P	Human

关联疾病

疾病名称

别名

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Acrocephalopolysyndactyly Type Iii

Sakati Syndrome	Sakati-Nyhan Syndrome
Acps With Leg Hypoplasia	Acps Iii
Acrocephalopolysyndactyly Type 3	Sakati-Nyhan-Tisdale Syndrome

Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor	PRLMNS
Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism	Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor
Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor	Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor
Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism	Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome
Renal Hamartomas Nephroblastomatosis And Fetal Gigantism	Nephroblastoma
Fetal Macrosomia

Central Precocious Puberty

Cpp	Gonadotropin-Dependant Precocious Puberty
Gonadotropin-Dependent Precocious Puberty	Precocious Puberty, Central

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome	Rtps
Atypical Teratoid/Rhabdoid Tumor	Rhabdoid Predisposition Syndrome
Familial Posterior Fossa Brain Tumor Of Infancy	Familial Rhabdoid Tumor
At/Rt	Atypical Teratoid Rhabdoid Tumour
Atypical Teratoid/Rhabdoid Tumour	Rhabdoid Tumor Of The Cns
Rhabdoid Tumour Of The Cns	Familial Posterior Fossa Brain Tumor Syndrome
Hereditary Swi/Snf Deficiency Syndrome	Atrt

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-115686	8-Azaadenosine	Inhibitor	99.94%	否
HY-168437	LIN28-IN-2	Inhibitor	/	否
HY-RS07672	LIN28B Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS19515	Lin28b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS26010	Lin28b Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	LIN28B	VGNC	VGNC:108131
Canis familiaris	LIN28B	VGNC	VGNC:42684
Felis catus	LIN28B	VGNC	VGNC:102449
Rattus norvegicus	LIN28B	RGD	RGD:1597432
Macaca mulatta	LIN28B	VGNC	VGNC:74175
Mus musculus	LIN28B	MGD	MGI:3584032

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LIN28B - lin-28 homolog B Gene

关于 LIN28B

功能概要

LIN28B 基因产物(2)

LIN28B 蛋白结构

LIN28B 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

LIN28B - lin-28 homolog B Gene

关于 LIN28B

功能概要

LIN28B 基因产物(2)

LIN28B 蛋白结构

LIN28B 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z