ARL1 - ADP ribosylation factor like GTPase 1 Gene

中文名称：ADP 核糖基化因子样 GTPase 1

种属: Homo sapiens

同用名: ARFL1

关于 ARL1

功能概要

该基因编码的蛋白质属于 ARL (ADP-核糖基化因子样) 蛋白质家族，在结构上与 ADP-核糖基化因子 (ARF) 相关。 ARF 被描述为霍乱毒素 (CT) ADP-核糖基转移酶活性的激活剂，可调节细胞内囊泡膜运输，并刺激磷脂酶 D (PLD) 亚型。尽管最初认为 ARL 蛋白不会激活 CT 或 PLD，但后来的研究表明它们是磷脂依赖性方式的 PLD 和 CT 的弱刺激物。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 7 月]

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a Phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]