1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Phospholipase

Phospholipase

Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipases are defined by the enzymatic reaction they catalyze. The classes are phospholipase A, which has members A1 and A2; phospholipase B, which can carry out the reactions of both A1 and A2; phospholipase C; and phospholipase D.

Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular processes and are also substrates for synthesis of other important signaling molecules. PLC is thus central to many important interlocking regulatory networks. Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival.

Phospholipase 相关产品 (28):

Cat. No. Product Name Effect Purity
  • HY-13419
    U-73122 Inhibitor 98.17%
    U-73122 是有效的 磷脂酶 C (phospholipase C) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 抑制剂,对磷脂酶 C 的 IC50 值约为 1-2.1 µM.
  • HY-70072
    D609 Inhibitor >98.0%
    D609 是一种选择性的磷脂酰胆碱特异性的磷脂酶C (phosphatidyl choline-specific phospholipase C) 抑制剂,Ki 值为 6.4 μM。
  • HY-13735A
    Quinacrine dihydrochloride Inhibitor 98.05%
    Quinacrine是一种荧光探针,使胆碱能受体蛋白发生构象转变,低μM水平对AML细胞具有作用活性,平均IC50为2.30 μM。
  • HY-10521
    Darapladib Inhibitor 99.95%
    Darapladib 是一种有效的脂蛋白相关磷脂酶A2 (Lp-PLA2) 抑制剂,IC50 为 0.25 nM。
  • HY-13402
    Varespladib Inhibitor 98.03%
    Varespladib (LY315920) 是高活性的人非胰腺分泌磷脂酶A2(sPLA)选择性抑制剂,IC50为7 nM。
  • HY-118628
    N-(p-amylcinnamoyl) Anthranilic Acid Inhibitor 98.81%
    N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 是一种广谱磷脂酶A2 (PLA2) 的抑制剂,TRP 通道的阻滞剂。N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 也是一种有效的钙离子激活氯通道 (calcium-activated chloride channels) 的可逆抑制剂,具有治疗心律失常的潜能。
  • HY-114190
    DB550
    DB550,靶向作用 PLCγ1,可破坏 CD95-PLCγ 1 之间的作用,抑制 Th17 驱动的炎症,而不影响 CD95-FADD 之间的作用。
  • HY-112605
    sPLA2-X Inhibitor 31 Inhibitor
    sPLA2-X Inhibitor 31 是一种选择性的分泌型磷脂酶 A2-X 抑制剂,抑制 sPLA2-XsPLA2-IIa,和 sPLA2-VIC50 分别为 26 nM,310 nM 和 2230 nM。
  • HY-P0233
    Melittin Activator
    Melittin 是一种PLA2激活剂。
  • HY-100736
    ML348 Inhibitor 99.59%
    ML348 是一个选择性的和可逆的 LYPLA1 抑制剂, IC50 值为 210 nM。
  • HY-12807
    FIPI Inhibitor 99.49%
    FIPI 是 halopemide 的衍生物,能够有效抑制 PLD1PLD2IC50 值分别为 25 nM 和 20 nM。
  • HY-N0134
    Tanshinone I Inhibitor >98.0%
    Tanshinone I 是一种IIA型人重组 sPLA2 和兔重组 cPLA2 抑制剂,IC50 分别为 11 μM 和 82 μM。
  • HY-100737
    ML349 Inhibitor 98.90%
    ML349 是一个有效且特异的酰基蛋白硫酯酶 2 (APT-2) 抑制剂,其 Ki 值为 120 nM。ML349 也是 LYPLA2 的抑制剂,其 IC50 值为 144 nM。
  • HY-18522
    AA26-9 Inhibitor 99.78%
    AA26-9是有效广谱的丝氨酸水解酶抑制剂。
  • HY-B0653A
    Levobupivacaine hydrochloride Inhibitor 99.85%
    Levobupivacaine hydrochloride 是一局部麻醉用化合物。
  • HY-10801
    CAY10650 Inhibitor >98.0%
    CAY10650是cPLA2α抑制剂,IC50为12 nM。
  • HY-103097
    ST271 Inhibitor 98.23%
    ST271 是一种蛋白质酪氨酸激酶 (PTK) 抑制剂,能够抑制 fMet-Leu-Phe 和 PAF 引起的 phospholipase D 活化,IC50 值分别为 6.7 和 9 μM。
  • HY-103334
    MAFP Inhibitor >98.0%
    MAFP (Methyl Arachidonyl Fluorophosphonate) 是选择性,针对活性位点,不可逆的 cPLA2iPLA2 抑制剂。 MAFP也是一种有效的不可逆的 anandamide amidase 抑制剂。
  • HY-111346
    1-Linoleoyl Glycerol Inhibitor >99.0%
    1-Linoleoyl Glycerol 是从 S. chinensis 根中分离的一种脂肪酸甘油。
  • HY-19757
    Lp-PLA2 -IN-1 Inhibitor 99.38%
    Lp-PLA2 -IN-1可以抑制 beta-lactamase-IN-1的活性,例如动脉粥样硬化,阿尔茨海默氏症。
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