LTBR - lymphotoxin beta receptor Gene

中文名称：淋巴毒素β受体

种属: Homo sapiens

同用名: TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III

关于 LTBR

功能概要

该基因编码肿瘤坏死因子受体超家族的一个成员。该受体的主要配体包括淋巴毒素 α/β 和肿瘤坏死因子配体超家族成员 14。编码的蛋白质在淋巴和其他器官发育、脂质代谢、免疫反应和程序性细胞死亡过程中发挥信号传导作用。这种受体的活性也与致癌作用有关。已经观察到编码多种同种型的可变剪接转录物变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]