BCAM - basal cell adhesion molecule (Lutheran blood group) Gene

中文名称：基底细胞粘附分子 (路德血型)

种属: Homo sapiens

同用名: AU; LU; CD239; MSK19

基因 ID: 4059 | 基因类型: protein coding

关于 BCAM

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,809,059-44,821,421 (from NCBI)

This gene has 9 transcripts (splice variants), 176 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 99.8), prostate (RPKM 62.6) and 19 other tissues.

功能概要

该基因编码 Lutheran 血型糖蛋白，它是免疫球蛋白超家族的成员，也是细胞外基质蛋白层粘连蛋白的受体。该蛋白质包含五个细胞外免疫球蛋白结构域、一个跨膜结构域和一个短的 C 末端胞质尾。这种蛋白质可能在上皮细胞癌和镰状细胞病中的红细胞血管阻塞中发挥作用。该基因的多态性定义了 Lutheran 系统和 Auberger 系统中的一些抗原。该基因的失活变体导致路德宗血型的隐性路德宗无效表型 Lu (ab-) 。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2012 年 5 月]

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell Cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

BCAM 基因产物(2)

mRNA	Protein	Name
NM_001013257.2	NP_001013275.1	basal cell adhesion molecule isoform 2 precursor
NM_005581.5	NP_005572.2	basal cell adhesion molecule isoform 1 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables laminin binding	IMP IMP: 通过突变表型推断	16236823	GOA
enables laminin receptor activity	IMP IMP: 通过突变表型推断	16236823	GOA
enables protein binding	IDA IDA: 通过直接分析推断	24453976	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell-matrix adhesion	IMP IMP: 通过突变表型推断	16236823	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BCAM 蛋白结构

Ig_2

C2-set_2

Ig_2

Ig_3

0
100
200
300
400
500
628 a.a.

蛋白主名

其他名称

basal cell adhesion molecule

Auberger b antigen

BCAM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BCAM	P50895	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
种属内	BCAM	P50895	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
种属内	BCAM	P50895	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
种属内	BCAM	P50895	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
种属内	BCAM	P50895	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
种属内	BCAM	P50895	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
种属内	BCAM	P50895	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
种属内	BCAM	P50895	TRIM7	Homo sapiens	Q9C029	Validated Y2H	32296183
种属内	BCAM	P50895	TRIM7	Homo sapiens	Q9C029	Y2H Prey Pooling	32296183
种属内	BCAM	P50895	TRIM7	Homo sapiens	Q9C029	Y2H Array	32296183
种属内	BCAM	P50895	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
种属内	BCAM	P50895	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
种属内	BCAM	P50895	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
种属内	BCAM	P50895	KLHL2	Homo sapiens	O95198	Validated Y2H	25910212
种属内	BCAM	P50895	KLHL2	Homo sapiens	O95198	Y2H Bait-Prey Pool	25910212
种属内	BCAM	P50895	KLHL2	Homo sapiens	O95198	Y2H Array	25910212
种属内	BCAM	P50895	KLHL2	Homo sapiens	O95198	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 BCAM 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7648	BCAM Protein, Human (HEK293, His)	P50895 (E32-A547)	≥95%

BCAM 抗体

目录号	产品名	应用	反应物种
HY-P82631	CD239 Antibody (YA2376)	WB, IHC-P, IP, FC	Human, Mouse, Rat
HY-P84368	CD239 Antibody (YA4065)	IHC-P, FC, ELISA	Human

关联疾病

疾病名称

别名

Lutheran Null

Recessive Lu Phenotype

Sickle Cell Disease

Hbs Disease	Hemoglobin S Disease
Scd	Sickle Cell Disorders
Sickling Disorder Due To Hemoglobin S	Anemia, Sickle Cell
Hb-Ss Disease Without Crisis	Hbss Without Crisis
Sickle-Cell Anaemia Without Crisis	Scd - [Sickle Cell Disease]
Sca - [Sickle Cell Anaemia]	Sickle Cell Disease Nos
Sickle Cell Disorder	Sickle Cell Syndrome
Sickle-Cell Anaemia Nos	Sickle-Cell Disorder Nos
Haemoglobin S Disease	Haemoglobin Ss Disease
Hb S Disease	Hb Ss Disease
Herrick Anaemia	Hereditary Haemoglobinopathy Disorder Homozygous For Haemoglobin S
Sickle-Cell Haemoglobin Disease	Sickling Disorder Due To Haemoglobin S
Hb-Ss Disease With Crisis	Sickle Cell Crisis
Sickle-Cell Disorder With Crisis	Sickle-Cell Anaemia With Crisis
Hbss With Crisis	Hb S Disease With Mention Of Crisis
Haemoglobin Ss Disease With Crisis	Hb-Ss Disease With Vaso-Occlusive Pain
Vaso-Occlusive Crisis

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Anemia, Congenital Dyserythropoietic, Type Iv

CDAN4	Congenital Dyserythropoietic Anemia Type Iv
Congenital Dyserythropoietic Anemia Type 4	Cda Iv
Cda Due To Klf1 Mutation	Cda Type 4
Cda Type Iv	Congenital Dyserythropoietic Anemia Due To Klf1 Mutation
Cda, Type Iv	Dyserythropoietic Anemia, Congenital, Type Iv
Congenital Dyserythropoietic Anaemia Due To Klf1 Mutation	Congenital Dyserythropoietic Anaemia Type 4
Congenital Dyserythropoietic Anaemia Type Iv	Anemia, Congenital Dyserythropoietic, 4
Anemia, Dyserythropoietic Congenital, Type Iv	Anemia, Dyserythropoietic, Congenital, Type Iv

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Sickle Cell Anemia

Hemoglobin Sc Disease	Anemia, Sickle Cell
Hbsc Disease	Sickle Cell-Hemoglobin C Disease Syndrome
Hb Ss Disease	Sickle Cell Trait
Drepanocytosis	Haemoglobin Sc Disease
Hb Sc Disease	Hb-S/Hb-C Disease
Hb-Ss Disease Without Crisis	Hemoglobin S Disease Without Crisis
Sickle Cell Anaemia	Sickle-Cell/Hb-C Disease Without Crisis
Sickle Cell - Hemoglobin C Disease	Hbs Disease
Hemoglobin S Disease	Sickling Disorder Due To Hemoglobin S
SKCA	Sickle Cell Disease
Sickle Cell-Hemoglobin C Disease	Sickle-Cell Disease Carrier
Sickle-Cell Heterozygous Disorder	Haemoglobin A-S Genotype
Hb-S - [Sickle Cell Haemoglobin] Carrier	Sickle Cell Haemoglobin Trait
As - [Sickle Cell Trait]	Hbas - [Sickle Cell Haemoglobin Trait]
Sickle-Cell Trait Haemoglobin Disease	Haemoglobin Sickle Cell Trait Disorder
Heterozygous Sickle Cell Trait	Hbas - [Heterozygous Haemoglobin S]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01393	BCAM Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS01403	BCAT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17632	Bcam Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24092	Bcam Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	BCAM	RGD	RGD:68378
Macaca mulatta	BCAM	VGNC	VGNC:108477
Canis familiaris	BCAM	VGNC	VGNC:49023
Mus musculus	BCAM	MGD	MGI:1929940
Bos taurus	BCAM	VGNC	VGNC:49138
Macaca fascicularis	BCAM	NCBI	NCBI:102137071
Others	BCAM	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BCAM - basal cell adhesion molecule (Lutheran blood group) Gene

关于 BCAM

功能概要

BCAM 基因产物(2)

BCAM 蛋白结构

BCAM 蛋白互作信息

重组 BCAM 蛋白

BCAM 抗体

关联疾病

直系同源

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BCAM - basal cell adhesion molecule (Lutheran blood group) Gene

关于 BCAM

功能概要

BCAM 基因产物(2)

BCAM 蛋白结构

BCAM 蛋白互作信息

重组 BCAM 蛋白

BCAM 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z