2. Gene
  3. THBS1 - Thbs1 thrombospondin 1 Gene

THBS1 - Thbs1 thrombospondin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Tsp1; TSP-1

基因 ID: 445442 | 基因类型: protein coding

关于 THBS1

功能概要

Enables transforming growth factor beta binding activity. Involved in several processes, including cellular response to tumor necrosis factor; positive regulation of transforming growth factor beta production; and response to testosterone. Located in cytoplasm and extracellular space. Biomarker of diabetic retinopathy; heart disease; myocardial infarction; and prostate Cancer. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human THBS1 (thrombospondin 1). [provided by Alliance of Genome Resources, Apr 2022]

THBS1 基因产物(2)

mRNA Protein Name
NM_001013062.3 NP_001013080.2 thrombospondin-1 isoform 1 precursor
NM_001398940.1 NP_001385869.1 thrombospondin-1 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables transforming growth factor beta binding IDA
IDA: 通过直接分析推断
10487979 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
15831915 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
15831915 RGD
involved in negative regulation of angiogenesis IDA
IDA: 通过直接分析推断
18772338 RGD
involved in positive regulation of transforming growth factor beta production IMP
IMP: 通过突变表型推断
17640965 RGD
involved in response to mechanical stimulus IMP
IMP: 通过突变表型推断
18772338 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
15665307 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
16754856 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

thrombospondin-1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14479 THBS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16903 Thbs1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23345 Thbs1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens THBS1 NCBI NCBI:7057
Mus musculus THBS1 NCBI NCBI:21825
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