1. Gene
  2. MTIF2 - mitochondrial translational initiation factor 2 Gene

MTIF2 - mitochondrial translational initiation factor 2 Gene

中文名称:线粒体翻译起始因子 2

种属: Homo sapiens

基因 ID: 4528 | 基因类型: protein coding

关于 MTIF2

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:55,236,595-55,269,248 (from NCBI)

This gene has 12 transcripts (splice variants), 189 orthologues and 18 paralogues. Ubiquitous expression in colon (RPKM 8.3), thyroid (RPKM 7.3) and 25 other tissues.

功能概要

在蛋白质生物合成的起始过程中,起始因子 2 (IF-2) 以 GTP 依赖性方式促进起始 tRNA 与核糖体小亚基的结合。原核生物 IF-2 是单一多肽,而真核细胞质 IF-2 (eIF-2) 是三聚体蛋白。牛肝线粒体含有 IF-2 (mt) ,这是一种相当于原核 IF-2 的 85-kD 单体蛋白。预测的 727 个氨基酸的人类蛋白质包含一个 29 个氨基酸的前序列。人类 IF-2 (mt) 与酵母 IF-2 (mt) 和几种原核 IF-2 具有 32% 到 38% 的氨基酸序列同一性,在蛋白质的 G 域中具有最大程度的保守性。[RefSeq 提供,2016 年 3 月]

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]

MTIF2 基因产物(7)

mRNA Protein Name
NM_001005369.1 NP_001005369.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321001.1 NP_001307930.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321002.1 NP_001307931.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321003.1 NP_001307932.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321004.1 NP_001307933.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321005.1 NP_001307934.1 translation initiation factor IF-2, mitochondrial isoform b
NM_002453.3 NP_002444.2 translation initiation factor IF-2, mitochondrial isoform a precursor

MTIF2 蛋白结构

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (181 - 341)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (369 - 430)

IF-2

IF-2: Translation-initiation factor 2 (510 - 607)

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  • 600
  • 727 a.a.
蛋白主名 其他名称

translation initiation factor IF-2, mitochondrial

IF-2mt

关联疾病

疾病名称 别名
Combined Oxidative Phosphorylation Deficiency 39

COXPD39

Combined Oxidative Phosphorylation Defect Type 39

Gfm2-Related Combined Oxidative Phosphorylation Defect

Combined Oxidative Phosphorylation Deficiency 3

Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3

COXPD3

Encephalomyopathy, Respiratory Failure, And Lactic Acidosis

Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis

Fatal Mitochondrial Disease Due To Coxpd3

Concentric Cardiomyopathy Hypotonia And Lactic Acidosis

Encephalomyopathy Respiratory Failure And Lactic Acidosis

Encephalomyopathy With Respiratory Failure And Lactic Acidosis

Combined Oxidative Phosphorylation Deficiency, Type 3

Combined Oxidative Phosphorylation Deficiency 1

Hepatoencephalopathy Due To Combined Oxidative Phosphorylation Defect Type 1

COXPD1

Early Fatal Progressive Hepatoencephalopathy

Hepatoencephalopathy Due To Coxpd1

Combined Oxidative Phosphorylation Deficiency, Type 1

Hepatoencephalopathy, Early Fatal Progressive

Hepatoencephalopathy Early Fatal Progressive

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MTIF2 RGD RGD:1303046
Mus musculus MTIF2 MGD MGI:1924034
Bos taurus MTIF2 VGNC VGNC:31733
Canis familiaris MTIF2 VGNC VGNC:43475
Macaca mulatta MTIF2 VGNC VGNC:75070
Felis catus MTIF2 VGNC VGNC:68341