2. Gene
  3. L1cam - L1 cell adhesion molecule Gene

L1cam - L1 cell adhesion molecule Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Hyd; Hsas; NgCAM; NCAML1; N-CAM L1

基因 ID: 50687 | 基因类型: protein coding

关于 L1cam

功能概要

Enables PDZ domain binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and generation of neurons. Located in several cellular components, including growth cone; membrane raft; and neuronal cell body. Is active in Schaffer collateral - CA1 synapse. Used to study hydrocephalus. Biomarker of anxiety disorder; hypothyroidism; and mental depression. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

L1cam 基因产物(1)

mRNA Protein Name
NM_017345.2 NP_059041.2 neural cell adhesion molecule L1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
11152476 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
18519736 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axonal fasciculation IMP
IMP: 通过突变表型推断
3856258 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
1377284 RGD
NOT involved in cellular response to ethanol IEP
IEP: 通过表达模式推断
18926887 RGD
involved in cellular response to ethanol IEP
IEP: 通过表达模式推断
21884525 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: 通过表达模式推断
3511068 RGD
involved in cellular response to thyroxine stimulus IEP
IEP: 通过表达模式推断
11085884 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
16686695 RGD
involved in cerebellar neuron development IMP
IMP: 通过突变表型推断
27027721 RGD
involved in dopaminergic neuron differentiation IEP
IEP: 通过表达模式推断
1350253 RGD
involved in modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
7997264 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
7997264 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
24841827 RGD
involved in positive regulation of axon extension IMP
IMP: 通过突变表型推断
18519736 RGD
involved in positive regulation of cell-substrate adhesion IDA
IDA: 通过直接分析推断
8636223 RGD
involved in protein localization to plasma membrane raft IDA
IDA: 通过直接分析推断
27027721 RGD
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
16478533 RGD
involved in regulation of neuron projection development IMP
IMP: 通过突变表型推断
27027721 RGD
involved in regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
27027721 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
12499861 RGD
involved in response to thyroid hormone IEP
IEP: 通过表达模式推断
11085884 RGD
involved in response to toluene IDA
IDA: 通过直接分析推断
27027721 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse EXP
EXP: 通过实验结果推断
7997264 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
7997264 RGD
located in axon IDA
IDA: 通过直接分析推断
18299352 RGD
located in axonal growth cone IDA
IDA: 通过直接分析推断
15355311 RGD
located in cell surface IDA
IDA: 通过直接分析推断
18299352 RGD
located in dendrite IDA
IDA: 通过直接分析推断
18299352 RGD
located in dendritic growth cone IDA
IDA: 通过直接分析推断
15355311 RGD
located in endosome IDA
IDA: 通过直接分析推断
18299352 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
18299352 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neural cell adhesion molecule L1

N-CAM-L1

NCAM-L1

NILE

nerve-growth factor-inducible large external glycoprotein

neuron-glia cell adhesion molecule

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07481 L1CAM Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18070 L1cam Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24545 L1cam Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens L1cam NCBI NCBI:3897
Mus musculus L1cam NCBI NCBI:16728
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